Development of Novel Formulation Strategies to Improve Pharmacokinetic Profile of Resveratrol
Resveratrol is a natural occurring polyphenol with diverse biological activities in vitro and poor pharmacokinetic profile because of its rapid metabolism in vivo. In this project, polymer conjugate approach was evaluated for masking resveratrol against the metabolism. Various polymer conjugates w...
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| Format: | Thesis |
| Language: | English |
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Curtin University
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/1741 |
| _version_ | 1848743755573624832 |
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| author | Basavaraj |
| author_facet | Basavaraj |
| author_sort | Basavaraj |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Resveratrol is a natural occurring polyphenol with diverse biological activities in vitro and poor pharmacokinetic profile because of its rapid metabolism in vivo. In this project, polymer conjugate approach was evaluated for masking resveratrol against the metabolism. Various polymer conjugates were prepared and evaluated both in vitro and in vivo. Among those tested, resveratrol-PLA-PEG and resveratrol-PEG ether conjugates were found capable of providing better pharmacokinetics than native resveratrol. |
| first_indexed | 2025-11-14T05:50:37Z |
| format | Thesis |
| id | curtin-20.500.11937-1741 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:50:37Z |
| publishDate | 2011 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-17412017-02-20T06:39:00Z Development of Novel Formulation Strategies to Improve Pharmacokinetic Profile of Resveratrol Basavaraj Resveratrol is a natural occurring polyphenol with diverse biological activities in vitro and poor pharmacokinetic profile because of its rapid metabolism in vivo. In this project, polymer conjugate approach was evaluated for masking resveratrol against the metabolism. Various polymer conjugates were prepared and evaluated both in vitro and in vivo. Among those tested, resveratrol-PLA-PEG and resveratrol-PEG ether conjugates were found capable of providing better pharmacokinetics than native resveratrol. 2011 Thesis http://hdl.handle.net/20.500.11937/1741 en Curtin University fulltext |
| spellingShingle | Basavaraj Development of Novel Formulation Strategies to Improve Pharmacokinetic Profile of Resveratrol |
| title | Development of Novel Formulation Strategies to Improve Pharmacokinetic Profile of Resveratrol |
| title_full | Development of Novel Formulation Strategies to Improve Pharmacokinetic Profile of Resveratrol |
| title_fullStr | Development of Novel Formulation Strategies to Improve Pharmacokinetic Profile of Resveratrol |
| title_full_unstemmed | Development of Novel Formulation Strategies to Improve Pharmacokinetic Profile of Resveratrol |
| title_short | Development of Novel Formulation Strategies to Improve Pharmacokinetic Profile of Resveratrol |
| title_sort | development of novel formulation strategies to improve pharmacokinetic profile of resveratrol |
| url | http://hdl.handle.net/20.500.11937/1741 |