Chemistry of clerodane diterpenes isolated from Dodonaea species in Western Australia
A new clerodane diterpene was isolated from the leaf resin of Dodonaea ceratocarpa in an appreciable quantity. The inherent chemistry of this new compound was studied to evaluate its potential as a starting material for the pharmaceutical industry. A suite of new clerodanes were synthesised.Cordytro...
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| Format: | Thesis |
| Language: | English |
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Curtin University
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/1738 |
| Summary: | A new clerodane diterpene was isolated from the leaf resin of Dodonaea ceratocarpa in an appreciable quantity. The inherent chemistry of this new compound was studied to evaluate its potential as a starting material for the pharmaceutical industry. A suite of new clerodanes were synthesised.Cordytropolone is a natural product isolated from Cordyceps that gave moderate inhibition against P. falciparum in vivo. A total synthesis was investigated using a thiophene-1,1-dioxide. |
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