Association between pre-eclampsia and locally derived traffic-related air pollution: A retrospective cohort study
Background - Pre-eclampsia is a common complication of pregnancy and is a major cause of fetal–maternal mortality and morbidity. Despite a number of plausible mechanisms by which air pollutants might contribute to this process, few studies have investigated the association between pre-eclampsia and...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/17326 |
| _version_ | 1848749436243542016 |
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| author | Pereira, Gavin Haggar, F. Shand, A. Bower, C. Cook, A. Nassar, N. |
| author_facet | Pereira, Gavin Haggar, F. Shand, A. Bower, C. Cook, A. Nassar, N. |
| author_sort | Pereira, Gavin |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background - Pre-eclampsia is a common complication of pregnancy and is a major cause of fetal–maternal mortality and morbidity. Despite a number of plausible mechanisms by which air pollutants might contribute to this process, few studies have investigated the association between pre-eclampsia and traffic emissions, a major contributor to air pollution in urban areas. Objective - The authors investigated the association between traffic-related air pollution and risk of pre-eclampsia in a maternal population in the urban centre of Perth, Western Australia. Method - The authors estimated maternal residential exposure to a marker for traffic-related air pollution (nitrogen dioxide, NO2) during pregnancy for 23 452 births using temporally adjusted land-use regression. Logistic regression was used to investigate associations with pre-eclampsia. Results - Each IQR increase in levels of traffic-related air pollution in whole pregnancy and third trimester was associated with a 12% (1%-25%) and 30% (7%-58%) increased risk of pre-eclampsia, respectively. The largest effect sizes were observed for women aged younger than 20 years or 40 years or older, aboriginal women and women with pre-existing and gestational diabetes, for whom an IQR increase in traffic-related air pollution in whole pregnancy was associated with a 34% (5%-72%), 35% (0%-82%) and 53% (7%-219%) increase in risk of pre-eclampsia, respectively. Conclusions - Elevated exposure to traffic-related air pollution in pregnancy was associated with increased risk of pre-eclampsia. Effect sizes were highest for elevated exposures in third trimester and among younger and older women, aboriginal women and women with diabetes. |
| first_indexed | 2025-11-14T07:20:54Z |
| format | Journal Article |
| id | curtin-20.500.11937-17326 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:20:54Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-173262017-09-13T15:42:44Z Association between pre-eclampsia and locally derived traffic-related air pollution: A retrospective cohort study Pereira, Gavin Haggar, F. Shand, A. Bower, C. Cook, A. Nassar, N. Background - Pre-eclampsia is a common complication of pregnancy and is a major cause of fetal–maternal mortality and morbidity. Despite a number of plausible mechanisms by which air pollutants might contribute to this process, few studies have investigated the association between pre-eclampsia and traffic emissions, a major contributor to air pollution in urban areas. Objective - The authors investigated the association between traffic-related air pollution and risk of pre-eclampsia in a maternal population in the urban centre of Perth, Western Australia. Method - The authors estimated maternal residential exposure to a marker for traffic-related air pollution (nitrogen dioxide, NO2) during pregnancy for 23 452 births using temporally adjusted land-use regression. Logistic regression was used to investigate associations with pre-eclampsia. Results - Each IQR increase in levels of traffic-related air pollution in whole pregnancy and third trimester was associated with a 12% (1%-25%) and 30% (7%-58%) increased risk of pre-eclampsia, respectively. The largest effect sizes were observed for women aged younger than 20 years or 40 years or older, aboriginal women and women with pre-existing and gestational diabetes, for whom an IQR increase in traffic-related air pollution in whole pregnancy was associated with a 34% (5%-72%), 35% (0%-82%) and 53% (7%-219%) increase in risk of pre-eclampsia, respectively. Conclusions - Elevated exposure to traffic-related air pollution in pregnancy was associated with increased risk of pre-eclampsia. Effect sizes were highest for elevated exposures in third trimester and among younger and older women, aboriginal women and women with diabetes. 2013 Journal Article http://hdl.handle.net/20.500.11937/17326 10.1136/jech-2011-200805 restricted |
| spellingShingle | Pereira, Gavin Haggar, F. Shand, A. Bower, C. Cook, A. Nassar, N. Association between pre-eclampsia and locally derived traffic-related air pollution: A retrospective cohort study |
| title | Association between pre-eclampsia and locally derived traffic-related air pollution: A retrospective cohort study |
| title_full | Association between pre-eclampsia and locally derived traffic-related air pollution: A retrospective cohort study |
| title_fullStr | Association between pre-eclampsia and locally derived traffic-related air pollution: A retrospective cohort study |
| title_full_unstemmed | Association between pre-eclampsia and locally derived traffic-related air pollution: A retrospective cohort study |
| title_short | Association between pre-eclampsia and locally derived traffic-related air pollution: A retrospective cohort study |
| title_sort | association between pre-eclampsia and locally derived traffic-related air pollution: a retrospective cohort study |
| url | http://hdl.handle.net/20.500.11937/17326 |