Specific inhibition of ectodomain shedding of glycoprotein lba by targeting its juxtamembrane shedding cleavage site

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Specific inhibition of ectodomain shedding of glycoprotein lba by targeting its juxtamembrane shedding cleavage site

Background: Ectodomain shedding of glycoprotein Ibα (GPIbα), a proteolytic event in which metalloprotease ADAM17 cleaves the Gly464-Val465 bond and releases glycocalicin to the plasma, is considered a critical step in mediating clearance of stored platelets. Supporting evidence has largely come from...

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Bibliographic Details
Main Authors:	Liang, X, Russell, S, Estelle, S, Jones, L, Cho, S, Khan, M, Berndt, Michael, Bunting, S, Ware, J, Li, R
Format:	Journal Article
Published:	Thieme Medical Publ Inc 2013
Online Access:	http://hdl.handle.net/20.500.11937/17298

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