Green Solvents for Eco-friendly Synthesis of Bioactive Heterocyclic Compounds
Use of safer solvents satisfies green chemistry practices. From the green chemistry perspective, the best solvent for reactions is no solvent. However, this ideal situation is not always achievable and choice of more eco-friendly solvents becomes critical. This chapter is dedicated to the synthesis...
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| Format: | Book Chapter |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/16992 |
| _version_ | 1848749335064346624 |
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| author | Dolzhenko, Anton Dolzhenko, A. |
| author2 | Goutam Brahmachari |
| author_facet | Goutam Brahmachari Dolzhenko, Anton Dolzhenko, A. |
| author_sort | Dolzhenko, Anton |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Use of safer solvents satisfies green chemistry practices. From the green chemistry perspective, the best solvent for reactions is no solvent. However, this ideal situation is not always achievable and choice of more eco-friendly solvents becomes critical. This chapter is dedicated to the synthesis of heterocyclic compounds using supercritical carbon dioxide and unconventional eco-friendly solvents with good biodegradability potential, such as polyethylene glycols (PEGs) and some bio-derived solvents (glycerol, ethyl lactate, and gluconic acid aqueous solution). These reaction media have enormous potential for use in medicinal chemistry with many advantages over conventional organic solvents. Supercritical carbon dioxide differs from the conventional solvents by its extremely low gas-like viscosity and great diffusivity. At the same time, supercritical carbon dioxide possesses an excellent profile from the health, safety, and environment perspective. Moreover, being an excellent solvent, supercritical carbon dioxide also acts as a very useful green reagent in a number of important transformations, including heterocyclizations. PEGs are nontoxic and biodegradable polymers with molecular weight ranging from 200 to 20,000 g/mol. This provides a good choice of PEGs for a better reaction outcome. In a number of reactions, PEG, being a solvent, also plays a role of a catalyst promoting the reaction. Bio-derived solvents such as glycerol, ethyl lactate, and gluconic acid possess enormous potential for heterocyclic chemistry, especially in combination with other green chemistry tools like microwave irradiation. Use of these unconventional solvents in the synthesis of heterocyclic compounds of biological importance is exemplified in this chapter. |
| first_indexed | 2025-11-14T07:19:18Z |
| format | Book Chapter |
| id | curtin-20.500.11937-16992 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:19:18Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-169922017-05-30T08:07:57Z Green Solvents for Eco-friendly Synthesis of Bioactive Heterocyclic Compounds Dolzhenko, Anton Dolzhenko, A. Goutam Brahmachari Gluconic acid Glycerol Supercritical carbon dioxide Bio-based product Ethyl lactate Bio-derived solvent Polyethylene glycol Solvent recyclability Biodegradable solvent Use of safer solvents satisfies green chemistry practices. From the green chemistry perspective, the best solvent for reactions is no solvent. However, this ideal situation is not always achievable and choice of more eco-friendly solvents becomes critical. This chapter is dedicated to the synthesis of heterocyclic compounds using supercritical carbon dioxide and unconventional eco-friendly solvents with good biodegradability potential, such as polyethylene glycols (PEGs) and some bio-derived solvents (glycerol, ethyl lactate, and gluconic acid aqueous solution). These reaction media have enormous potential for use in medicinal chemistry with many advantages over conventional organic solvents. Supercritical carbon dioxide differs from the conventional solvents by its extremely low gas-like viscosity and great diffusivity. At the same time, supercritical carbon dioxide possesses an excellent profile from the health, safety, and environment perspective. Moreover, being an excellent solvent, supercritical carbon dioxide also acts as a very useful green reagent in a number of important transformations, including heterocyclizations. PEGs are nontoxic and biodegradable polymers with molecular weight ranging from 200 to 20,000 g/mol. This provides a good choice of PEGs for a better reaction outcome. In a number of reactions, PEG, being a solvent, also plays a role of a catalyst promoting the reaction. Bio-derived solvents such as glycerol, ethyl lactate, and gluconic acid possess enormous potential for heterocyclic chemistry, especially in combination with other green chemistry tools like microwave irradiation. Use of these unconventional solvents in the synthesis of heterocyclic compounds of biological importance is exemplified in this chapter. 2014 Book Chapter http://hdl.handle.net/20.500.11937/16992 Elsevier restricted |
| spellingShingle | Gluconic acid Glycerol Supercritical carbon dioxide Bio-based product Ethyl lactate Bio-derived solvent Polyethylene glycol Solvent recyclability Biodegradable solvent Dolzhenko, Anton Dolzhenko, A. Green Solvents for Eco-friendly Synthesis of Bioactive Heterocyclic Compounds |
| title | Green Solvents for Eco-friendly Synthesis of Bioactive Heterocyclic Compounds |
| title_full | Green Solvents for Eco-friendly Synthesis of Bioactive Heterocyclic Compounds |
| title_fullStr | Green Solvents for Eco-friendly Synthesis of Bioactive Heterocyclic Compounds |
| title_full_unstemmed | Green Solvents for Eco-friendly Synthesis of Bioactive Heterocyclic Compounds |
| title_short | Green Solvents for Eco-friendly Synthesis of Bioactive Heterocyclic Compounds |
| title_sort | green solvents for eco-friendly synthesis of bioactive heterocyclic compounds |
| topic | Gluconic acid Glycerol Supercritical carbon dioxide Bio-based product Ethyl lactate Bio-derived solvent Polyethylene glycol Solvent recyclability Biodegradable solvent |
| url | http://hdl.handle.net/20.500.11937/16992 |