Modelling of embolus transport and embolic stroke
Cerebral microembolism may lead to the restriction of blood supply due to damaged blood vessel tissue (focal ischemia) which is increasingly seen as the cause of cognitive deterioration including Alzheimer’s disease and vascular dementia.The flow through fractal models of the peripheral vasculature...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Book Chapter |
| Published: |
WIT Press
2011
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/16640 |
| _version_ | 1848749234318213120 |
|---|---|
| author | Sutalo, Iiija Bui, A. Liffman, Kurt Manasseh, R. |
| author2 | C.A. Brebbia |
| author_facet | C.A. Brebbia Sutalo, Iiija Bui, A. Liffman, Kurt Manasseh, R. |
| author_sort | Sutalo, Iiija |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Cerebral microembolism may lead to the restriction of blood supply due to damaged blood vessel tissue (focal ischemia) which is increasingly seen as the cause of cognitive deterioration including Alzheimer’s disease and vascular dementia.The flow through fractal models of the peripheral vasculature of the Anterior Cerebral Arteries (ACA) and Middle Cerebral Arteries (MCA) was modelled.The multi-scale model of the cerebral vasculature was coupled with blood flow and embolus transport models.The model incorporated asymmetric bifurcation trees, embolus-vascular interactions and autoregulation.Simulations were carried out where the embolus deposition rate, embolus diameter and embolus introduction rate were varied.Increasing the embolus diameter and embolus introduction rate increased the number of blocked terminal arteries to a quasi steady-state.For a low embolus deposition rate the MCA and ACA territory had the same embolization dynamics, even though, the MCA was larger than the ACA.It was also found for a higher embolus deposition rate the MCA, due to its more expansive structure, was less prone to occlusion than the ACA. The results also showed the effect of a single blockage is expected to be less severe in asymmetric flow than symmetric flow. |
| first_indexed | 2025-11-14T07:17:42Z |
| format | Book Chapter |
| id | curtin-20.500.11937-16640 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:17:42Z |
| publishDate | 2011 |
| publisher | WIT Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-166402023-01-27T05:26:31Z Modelling of embolus transport and embolic stroke Sutalo, Iiija Bui, A. Liffman, Kurt Manasseh, R. C.A. Brebbia M. Eglite I. Knets R. Miftahof V. Popov damaged blood vessel tissue cognitive deterioration asymmetric bifurcation trees embolus transport models vascular dementia Alzheimer’s disease embolus-vascular interactions Cerebral microembolism Middle Cerebral Arteries (MCA) Anterior Cerebral Arteries (ACA) cerebral vasculature autoregulation Cerebral microembolism may lead to the restriction of blood supply due to damaged blood vessel tissue (focal ischemia) which is increasingly seen as the cause of cognitive deterioration including Alzheimer’s disease and vascular dementia.The flow through fractal models of the peripheral vasculature of the Anterior Cerebral Arteries (ACA) and Middle Cerebral Arteries (MCA) was modelled.The multi-scale model of the cerebral vasculature was coupled with blood flow and embolus transport models.The model incorporated asymmetric bifurcation trees, embolus-vascular interactions and autoregulation.Simulations were carried out where the embolus deposition rate, embolus diameter and embolus introduction rate were varied.Increasing the embolus diameter and embolus introduction rate increased the number of blocked terminal arteries to a quasi steady-state.For a low embolus deposition rate the MCA and ACA territory had the same embolization dynamics, even though, the MCA was larger than the ACA.It was also found for a higher embolus deposition rate the MCA, due to its more expansive structure, was less prone to occlusion than the ACA. The results also showed the effect of a single blockage is expected to be less severe in asymmetric flow than symmetric flow. 2011 Book Chapter http://hdl.handle.net/20.500.11937/16640 WIT Press restricted |
| spellingShingle | damaged blood vessel tissue cognitive deterioration asymmetric bifurcation trees embolus transport models vascular dementia Alzheimer’s disease embolus-vascular interactions Cerebral microembolism Middle Cerebral Arteries (MCA) Anterior Cerebral Arteries (ACA) cerebral vasculature autoregulation Sutalo, Iiija Bui, A. Liffman, Kurt Manasseh, R. Modelling of embolus transport and embolic stroke |
| title | Modelling of embolus transport and embolic stroke |
| title_full | Modelling of embolus transport and embolic stroke |
| title_fullStr | Modelling of embolus transport and embolic stroke |
| title_full_unstemmed | Modelling of embolus transport and embolic stroke |
| title_short | Modelling of embolus transport and embolic stroke |
| title_sort | modelling of embolus transport and embolic stroke |
| topic | damaged blood vessel tissue cognitive deterioration asymmetric bifurcation trees embolus transport models vascular dementia Alzheimer’s disease embolus-vascular interactions Cerebral microembolism Middle Cerebral Arteries (MCA) Anterior Cerebral Arteries (ACA) cerebral vasculature autoregulation |
| url | http://hdl.handle.net/20.500.11937/16640 |