Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2-amines.

QR Code

Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2-amines.

Several 4-substituted 1,3,5-triazino[1,2-a]benzimidazol-2-amines were prepared via cyclization of 2-benzimidazolylguanidine with various reactants. The prototropic tautomerism in the obtained dihydro analogs was investigated. According to the NMR data, the 3,4-dihydro form was found to predominate i...

Full description

Bibliographic Details
Main Authors:	Dolzhenko, Anton, Chui, W.
Format:	Journal Article
Published:	Springer 2007
Online Access:	http://hdl.handle.net/20.500.11937/16544

Similar Items

Simple synthesis of 2-amino-4-(het)aryl-4,6-dihydro-1(3)(11)H-[1,3,5]triazino[2,1-b]quinazolin-6-ones
by: Dolzhenko, Anton, et al.
Published: (2008)

Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines
by: Dolzhenko, Anton, et al.
Published: (2015)

Synthesis of 5,7-Diamino[1,2,4]triazolo[1,2-a][1,3,5]triazines via Annulation of 1,3,5-Triazine Ring onto 3(5)-Amino-1,2,4-trizoles
by: Dolzhenko, Anton, et al.
Published: (2007)

Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines.
by: Dolzhenko, Anton, et al.
Published: (2008)

Synthesis and structure of 3,4-dihydropyrido[2’,3’:3,4]pyrazolo[1,5-a][1,3,5]triazin-2-amines
by: Dolzhenko, Anton, et al.
Published: (2012)

Pyrazolo[1,5-a][1,3,5]triazines(5-Aza-9-deazapurines): Synthesis and Biological Activity
by: Dolzhenko, Anton, et al.
Published: (2008)

An efficient synthesis of 2,4,7-trisubstituted pyrimido[1,2-a][1,3,5]triazin-6-ones
by: Sachdeva, N., et al.
Published: (2015)

7-(4-Fluorobenzylamino)-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine methanol disolvate
by: Dolzhenko, Anton, et al.
Published: (2011)

Advances in chemistry and biological activity of fluorinated 1,3,5-triazines
by: Dolzhenko, Anton, et al.
Published: (2007)

Advances in chemistry and biological activity of fluorinated 1,3,5-triazines
by: Dolzhenko, Anton, et al.
Published: (2012)

7-Dimethylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine methanol solvate.
by: Dolzhenko, Anton, et al.
Published: (2008)

4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity
by: Lim, Felicia Phei Lin, et al.
Published: (2014)

7,7-Dimethyl-2-phenyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine.
by: Dolzhenko, Anton, et al.
Published: (2007)

Synthetic routes towards pyrimido[1,2-a][1,3,5]triazines (Review)
by: Dolzhenko, Anton
Published: (2011)

Practical synthesis of regioisomeric 5(7)-amino-6,7(4,5)-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazines
by: Dolzhenko, Anton, et al.
Published: (2007)

Synthesis and tautomerism study of 6-benzoylmethyl-1,3,5-triazin-2,4-diamine
by: Sachdeva, N., et al.
Published: (2011)

Crystal structure of 7-(4-methylphenyl)imidazo[1,2-a][1,3,5]triazin-4-amine, C12H11N5
by: Lim, F., et al.
Published: (2018)

Molecular and Crystal Structure of 7,7-Dimethyl-2-pyridin-4-yl-6,7-dihydro-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine [1]
by: Dolzhenko, Anton, et al.
Published: (2011)

4,4-Dimethyl-3,4-dihydropyrido[2',3':3,4]pyrazolo[1,5-a ][1,3,5]triazin-2-amine ethanol monosolvate
by: Dolzhenko, Anton, et al.
Published: (2011)

Regioselective synthesis of pyrimido [1,2-a][1,3,5]triazin-6-ones via reaction of 1-(6-oxo-1,6-dihydropyrimidin-2-yl)guanidines with triethylorthoacetate: Observation of an unexpected rearrangement
by: Sachdeva, N., et al.
Published: (2012)

4-Amino-2,8-dimethyl-6H-pyrimido[1,2-a][1,3,5]triazin-6-one
by: Sachdeva, N., et al.
Published: (2010)

Crystal structure of 7-(4-methylphenyl)imidazo[1,2-a][1,3,5]triazin-4-amine, C12H11N5
by: Lim, Felicia Phei Lin, et al.
Published: (2018)

3-Phenyl-1H-1,2,4-triazol-5-amine-5-phenyl-1H-1,2,4-triazol-3-amine (1/1).
by: Dolzhenko, Anton, et al.
Published: (2009)

2-Phenyl-7-(4-pyridylmethylamino)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5(4H)-one
by: Dolzhenko, Anton, et al.
Published: (2011)

2-Amino-4-(4-bromophenyl)-8-trifluoromethyl-3,4-dihydropyrimido[1,2-a][1,3,5]triazin-6(5H)-one
by: Dolzhenko, Anton, et al.
Published: (2009)

Synthesis and in vitro evaluation of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives as thymidine phosphorylase inhibitors
by: Bera, H., et al.
Published: (2013)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-: A] [1,3,5]triazines
by: Lim, F., et al.
Published: (2018)

Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones
by: Bera, H., et al.
Published: (2013)

3-Pyridin-2-yl-1H-1,2,4-triazol-5-amine.
by: Dolzhenko, Anton, et al.
Published: (2009)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines
by: Lim, Felicia Phei Lin, et al.
Published: (2018)

4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one
by: Smolnikov, S., et al.
Published: (2017)

Synthesis of novel trichloromethyl substituted azolo[1,3,5]triazines
by: Kalinin, D., et al.
Published: (2012)

Synthesis of New Heterocyclic System: 1(5)H-1,5-Diazacycl[3.3.2]azine-2,4-dione
by: Dolzhenko, Anton, et al.
Published: (2007)

A one-pot, three-component, microwave-promoted synthesis of 2-amino-substituted 7-amino-1,2,4-triazolo[1,5-a][1,3,5]triazines
by: Kalinina, S., et al.
Published: (2013)

Synthesis, in vitro evaluation of thymidine phosphorylase inhibitory activity, and in silico study of 1,3,5-triazin-2,4-dione and its fused analogues
by: Bera, H., et al.
Published: (2013)

Synthetic Routes towards Thiazolo[1,3,5]triazines (Review)
by: Dolzhenko, Anton
Published: (2011)

A New one-pot three-component synthesis of 4-Aryl-6-cycloamino-1,3,5-triazin-2-amines under microwave irradiation
by: Muhammad Syafiq, S, et al.
Published: (2021)

A new synthesis of amino substituted azolo[1,3,5]triazines via reaction of N1,N1-dimethyl-N2-azolylformamidines with cyanamide
by: Kalinin, D., et al.
Published: (2013)

A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5] triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities
by: Bera, H., et al.
Published: (2013)

A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines
by: Dolzhenko, Anton, et al.
Published: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ckgld75faaqpdplo3vs4a71rkb