Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea

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Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea

Background: In northern Papua New Guinea (PNG), most Plasmodium falciparum isolates proved resistant to chloroquine (CQ) in vitro between 2005 and 2007, and there was near-fixation of pfcrt K76T, pfdhfr C59R/S108N and pfmdr1 N86Y. To determine whether the subsequent introduction of artemisinin combi...

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Bibliographic Details
Main Authors:	Koleala, T., Karl, S., Laman, M., Moore, Brioni, Benjamin, J., Barnadas, C., Robinson, L., Kattenberg, J., Javati, S., Wong, R., Rosanas-Urgell, A., Betuela, I., Siba, P., Mueller, I., Davis, T.
Format:	Journal Article
Published:	BioMed Central 2015
Online Access:	http://hdl.handle.net/20.500.11937/16467

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