Use of quantitative pharmacology tools to improve malaria treatments
The use of pharmacokinetic (PK) and pharmacodynamic (PD) data to inform antimalarial treatment regimens has accelerated in the past few decades, due in no small part to the stimulus provided by progressive development of parasite resistance to most of the currently available drugs. An understanding...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/16310 |
| _version_ | 1848749139390627840 |
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| author | Davis, T. Moore, B. Salman, S. Page-Sharp, Madhu Batty, Kevin Manning, L. |
| author_facet | Davis, T. Moore, B. Salman, S. Page-Sharp, Madhu Batty, Kevin Manning, L. |
| author_sort | Davis, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The use of pharmacokinetic (PK) and pharmacodynamic (PD) data to inform antimalarial treatment regimens has accelerated in the past few decades, due in no small part to the stimulus provided by progressive development of parasite resistance to most of the currently available drugs. An understanding of the disposition, interactions, efficacy and toxicity of the mainstay of contemporary antimalarial treatment, artemisinin combination therapy (ACT), has been facilitated by PK/PD studies which have been used to refine treatment regimens across the spectrum of disease, especially in special groups including young children and pregnant women. The present review highlights recent clinically-important examples of the ways in which these quantitative pharmacology tools have been applied to improve ACT, as well as 8-aminoquinoline use and the characterisation of novel antimalarial therapies such as the spiroindolones. |
| first_indexed | 2025-11-14T07:16:11Z |
| format | Journal Article |
| id | curtin-20.500.11937-16310 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:16:11Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-163102017-09-13T15:04:07Z Use of quantitative pharmacology tools to improve malaria treatments Davis, T. Moore, B. Salman, S. Page-Sharp, Madhu Batty, Kevin Manning, L. The use of pharmacokinetic (PK) and pharmacodynamic (PD) data to inform antimalarial treatment regimens has accelerated in the past few decades, due in no small part to the stimulus provided by progressive development of parasite resistance to most of the currently available drugs. An understanding of the disposition, interactions, efficacy and toxicity of the mainstay of contemporary antimalarial treatment, artemisinin combination therapy (ACT), has been facilitated by PK/PD studies which have been used to refine treatment regimens across the spectrum of disease, especially in special groups including young children and pregnant women. The present review highlights recent clinically-important examples of the ways in which these quantitative pharmacology tools have been applied to improve ACT, as well as 8-aminoquinoline use and the characterisation of novel antimalarial therapies such as the spiroindolones. 2015 Journal Article http://hdl.handle.net/20.500.11937/16310 10.1586/17512433.2016.1129273 restricted |
| spellingShingle | Davis, T. Moore, B. Salman, S. Page-Sharp, Madhu Batty, Kevin Manning, L. Use of quantitative pharmacology tools to improve malaria treatments |
| title | Use of quantitative pharmacology tools to improve malaria treatments |
| title_full | Use of quantitative pharmacology tools to improve malaria treatments |
| title_fullStr | Use of quantitative pharmacology tools to improve malaria treatments |
| title_full_unstemmed | Use of quantitative pharmacology tools to improve malaria treatments |
| title_short | Use of quantitative pharmacology tools to improve malaria treatments |
| title_sort | use of quantitative pharmacology tools to improve malaria treatments |
| url | http://hdl.handle.net/20.500.11937/16310 |