Electrospun PLA/PCL/MPs Nanofibrous Hybrid Composite Structures for Sustained Drug Release
Electrospun nanofibrous hybrid composite structures were prepared by blending poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) solutions and then mixed with three different amounts (0.01, 0.1 and 1% wt/v) of iron oxide (Fe3O4) magnetic nanoparticles (MPs),carrying a therapeutic compound tetrac...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Conference Paper |
| Published: |
University of Padova, Italy
2012
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/16241 |
| _version_ | 1848749119457198080 |
|---|---|
| author | Haroosh, Hazim Dong, Yu |
| author2 | Marino Quaresimin |
| author_facet | Marino Quaresimin Haroosh, Hazim Dong, Yu |
| author_sort | Haroosh, Hazim |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Electrospun nanofibrous hybrid composite structures were prepared by blending poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) solutions and then mixed with three different amounts (0.01, 0.1 and 1% wt/v) of iron oxide (Fe3O4) magnetic nanoparticles (MPs),carrying a therapeutic compound tetracycline hydrochloride (TCH) with the potential use for medical applications. The material system was investigated to understand how constituents of hybrid composites influenced the surface morphology to control drug release. It has been found that fibre properties are strongly related to the viscosity and electrical conductivity of prepared solutions. The addition of MPs increased moderately the solution viscosities and produced quite uniform nanofibres. The fibre diameter decreased with increasing MP concentration due to significantly enhanced solution conductivity in presence of MPs. Crystallinity and Tg of PCL and Tc of PLA decreased when MPs were mixed with the polymer blend. TCH loading appears to result in decreasing nanofibre diameters and cause to decrease Tg and Tm values of PCL. TCH release was accelerated by adding MPs to the blended polymers. |
| first_indexed | 2025-11-14T07:15:52Z |
| format | Conference Paper |
| id | curtin-20.500.11937-16241 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:15:52Z |
| publishDate | 2012 |
| publisher | University of Padova, Italy |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-162412023-02-02T07:57:38Z Electrospun PLA/PCL/MPs Nanofibrous Hybrid Composite Structures for Sustained Drug Release Haroosh, Hazim Dong, Yu Marino Quaresimin Valter Carvelli Alessandro Pegoretti Nicola Trevisan Hybrid composites Electrospinning Drug release Magnetic nanoparticles Electrospun nanofibrous hybrid composite structures were prepared by blending poly(ε-caprolactone) (PCL) and poly(lactic acid) (PLA) solutions and then mixed with three different amounts (0.01, 0.1 and 1% wt/v) of iron oxide (Fe3O4) magnetic nanoparticles (MPs),carrying a therapeutic compound tetracycline hydrochloride (TCH) with the potential use for medical applications. The material system was investigated to understand how constituents of hybrid composites influenced the surface morphology to control drug release. It has been found that fibre properties are strongly related to the viscosity and electrical conductivity of prepared solutions. The addition of MPs increased moderately the solution viscosities and produced quite uniform nanofibres. The fibre diameter decreased with increasing MP concentration due to significantly enhanced solution conductivity in presence of MPs. Crystallinity and Tg of PCL and Tc of PLA decreased when MPs were mixed with the polymer blend. TCH loading appears to result in decreasing nanofibre diameters and cause to decrease Tg and Tm values of PCL. TCH release was accelerated by adding MPs to the blended polymers. 2012 Conference Paper http://hdl.handle.net/20.500.11937/16241 University of Padova, Italy restricted |
| spellingShingle | Hybrid composites Electrospinning Drug release Magnetic nanoparticles Haroosh, Hazim Dong, Yu Electrospun PLA/PCL/MPs Nanofibrous Hybrid Composite Structures for Sustained Drug Release |
| title | Electrospun PLA/PCL/MPs Nanofibrous Hybrid Composite Structures for Sustained Drug Release |
| title_full | Electrospun PLA/PCL/MPs Nanofibrous Hybrid Composite Structures for Sustained Drug Release |
| title_fullStr | Electrospun PLA/PCL/MPs Nanofibrous Hybrid Composite Structures for Sustained Drug Release |
| title_full_unstemmed | Electrospun PLA/PCL/MPs Nanofibrous Hybrid Composite Structures for Sustained Drug Release |
| title_short | Electrospun PLA/PCL/MPs Nanofibrous Hybrid Composite Structures for Sustained Drug Release |
| title_sort | electrospun pla/pcl/mps nanofibrous hybrid composite structures for sustained drug release |
| topic | Hybrid composites Electrospinning Drug release Magnetic nanoparticles |
| url | http://hdl.handle.net/20.500.11937/16241 |