4-Hydroxy-trans-2-nonenal (4-HNE) induces neuronal SH-SY5Y cell death via hampering ATP binding at kinase domain of Akt1

4-Hydroxy-trans-2-nonenal (4-HNE) induces neuronal SH-SY5Y cell death via hampering ATP binding at kinase domain of Akt1

Inhibition mechanism(s) of protein kinase B/Akt1 and its consequences on related cell signaling were investigated in human neuroblastoma SH-SY5Y cells exposed to 4-hydroxy-trans-2-nonenal (4-HNE), one of the most reactive aldehyde by-products of lipid peroxidation. In silico data indicate that 4-HNE...

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Bibliographic Details
Main Authors: Kashyap, M., Singh, A., Yadav, D., Siddiqui, M., Srivastava, R., Chaturvedi, Vishal, Rai, N.
Format: Journal Article
Published: Springer 2015
Subjects:
Akt/Pkb
Neuronal SH-SY5Y Cells
Apoptosis
4-HNE
Molecular modeling
Online Access:http://hdl.handle.net/20.500.11937/15975

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