4-Hydroxy-trans-2-nonenal (4-HNE) induces neuronal SH-SY5Y cell death via hampering ATP binding at kinase domain of Akt1

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4-Hydroxy-trans-2-nonenal (4-HNE) induces neuronal SH-SY5Y cell death via hampering ATP binding at kinase domain of Akt1

Inhibition mechanism(s) of protein kinase B/Akt1 and its consequences on related cell signaling were investigated in human neuroblastoma SH-SY5Y cells exposed to 4-hydroxy-trans-2-nonenal (4-HNE), one of the most reactive aldehyde by-products of lipid peroxidation. In silico data indicate that 4-HNE...

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Bibliographic Details
Main Authors:	Kashyap, M., Singh, A., Yadav, D., Siddiqui, M., Srivastava, R., Chaturvedi, Vishal, Rai, N.
Format:	Journal Article
Published:	Springer 2015
Subjects:	Akt/Pkb Neuronal SH-SY5Y Cells Apoptosis 4-HNE Molecular modeling
Online Access:	http://hdl.handle.net/20.500.11937/15975

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