African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles
Background: Several studies have demonstrated a lower apolipoprotein E4 (APOE e4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier Inc.
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/15480 |
| _version_ | 1848748904498069504 |
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| author | Roses, A. Lutz, M. Saunders, A. Goldgaber, D. Saul, R. Sundseth, S. Akkari, Patrick Roses, S. Gottschalk, W. Whitfield, K. Vostrov, A. Hauser, M. Allingham, R. Burns, D. Chiba-Falek, O. Welsh-Bohmer, K. |
| author_facet | Roses, A. Lutz, M. Saunders, A. Goldgaber, D. Saul, R. Sundseth, S. Akkari, Patrick Roses, S. Gottschalk, W. Whitfield, K. Vostrov, A. Hauser, M. Allingham, R. Burns, D. Chiba-Falek, O. Welsh-Bohmer, K. |
| author_sort | Roses, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Several studies have demonstrated a lower apolipoprotein E4 (APOE e4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes. Methods: We have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/APOE genomic region in West African, Caucasian, and African-American cohorts. Results: African-American haplotype frequency scans of poly-T lengths connected in phase with either APOE e4 or APOE e3 differ from both West Africans and Caucasians and represent admixture of several distinct West African and Caucasian haplotypes. A new West African TOMM40'523 haplotype, with APOE e4 connected to a short TOMM40'523 allele, is observed in African-Americans but not Caucasians. Conclusion: These data have therapeutic implications for the age of onset risk algorithm estimates and the design of a prevention trial for African-Americans or other mixed ethnic populations. |
| first_indexed | 2025-11-14T07:12:27Z |
| format | Journal Article |
| id | curtin-20.500.11937-15480 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:12:27Z |
| publishDate | 2014 |
| publisher | Elsevier Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-154802017-09-13T13:41:03Z African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles Roses, A. Lutz, M. Saunders, A. Goldgaber, D. Saul, R. Sundseth, S. Akkari, Patrick Roses, S. Gottschalk, W. Whitfield, K. Vostrov, A. Hauser, M. Allingham, R. Burns, D. Chiba-Falek, O. Welsh-Bohmer, K. Background: Several studies have demonstrated a lower apolipoprotein E4 (APOE e4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes. Methods: We have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/APOE genomic region in West African, Caucasian, and African-American cohorts. Results: African-American haplotype frequency scans of poly-T lengths connected in phase with either APOE e4 or APOE e3 differ from both West Africans and Caucasians and represent admixture of several distinct West African and Caucasian haplotypes. A new West African TOMM40'523 haplotype, with APOE e4 connected to a short TOMM40'523 allele, is observed in African-Americans but not Caucasians. Conclusion: These data have therapeutic implications for the age of onset risk algorithm estimates and the design of a prevention trial for African-Americans or other mixed ethnic populations. 2014 Journal Article http://hdl.handle.net/20.500.11937/15480 10.1016/j.jalz.2014.06.009 Elsevier Inc. unknown |
| spellingShingle | Roses, A. Lutz, M. Saunders, A. Goldgaber, D. Saul, R. Sundseth, S. Akkari, Patrick Roses, S. Gottschalk, W. Whitfield, K. Vostrov, A. Hauser, M. Allingham, R. Burns, D. Chiba-Falek, O. Welsh-Bohmer, K. African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles |
| title | African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles |
| title_full | African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles |
| title_fullStr | African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles |
| title_full_unstemmed | African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles |
| title_short | African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles |
| title_sort | african-american tomm40'523-apoe haplotypes are admixture of west african and caucasian alleles |
| url | http://hdl.handle.net/20.500.11937/15480 |