Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency
It remains unclear why some individuals and not others are susceptible to non-tuberculous mycobacterial lung disease (NTMLD). To determine whether NTMLD is associated with defects or biases in Th1/Th2/Th17 immunity, blood leukocytes from NTM patients with nodular bronchiectasis, their adult offsprin...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Academic Press
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/15281 |
| _version_ | 1848748851080462336 |
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| author | Lim, A. Allison, C. Price, Patricia Waterer, G. |
| author_facet | Lim, A. Allison, C. Price, Patricia Waterer, G. |
| author_sort | Lim, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | It remains unclear why some individuals and not others are susceptible to non-tuberculous mycobacterial lung disease (NTMLD). To determine whether NTMLD is associated with defects or biases in Th1/Th2/Th17 immunity, blood leukocytes from NTM patients with nodular bronchiectasis, their adult offspring, and healthy population controls were stimulated with staphylococcal enterotoxin B (SEB), tuberculin and sensitin to measure cytokine production. In response to SEB, NTM patients exhibited higher frequencies of IFN?-producing CD4 + T cells than population controls (P<0.001). In supernatant, levels of IL-17 were lower in patients than adult offspring. Sensitin elicited higher IFN? responses from patients than controls (P<0.05). Patients also produced more IL-10 in supernatant than controls after culture with tuberculin (P<0.01) or sensitin (P<0.05), but IL-10-producing CD4 + T cells were undetectable. NTMLD is not associated with deficient IFN? production, but may be associated with reduced Th17 immunity and/or a predisposition towards IL-10 production from non-CD4 + T cells. © 2010 Elsevier Inc. |
| first_indexed | 2025-11-14T07:11:36Z |
| format | Journal Article |
| id | curtin-20.500.11937-15281 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:11:36Z |
| publishDate | 2010 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-152812017-09-13T13:40:19Z Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency Lim, A. Allison, C. Price, Patricia Waterer, G. It remains unclear why some individuals and not others are susceptible to non-tuberculous mycobacterial lung disease (NTMLD). To determine whether NTMLD is associated with defects or biases in Th1/Th2/Th17 immunity, blood leukocytes from NTM patients with nodular bronchiectasis, their adult offspring, and healthy population controls were stimulated with staphylococcal enterotoxin B (SEB), tuberculin and sensitin to measure cytokine production. In response to SEB, NTM patients exhibited higher frequencies of IFN?-producing CD4 + T cells than population controls (P<0.001). In supernatant, levels of IL-17 were lower in patients than adult offspring. Sensitin elicited higher IFN? responses from patients than controls (P<0.05). Patients also produced more IL-10 in supernatant than controls after culture with tuberculin (P<0.01) or sensitin (P<0.05), but IL-10-producing CD4 + T cells were undetectable. NTMLD is not associated with deficient IFN? production, but may be associated with reduced Th17 immunity and/or a predisposition towards IL-10 production from non-CD4 + T cells. © 2010 Elsevier Inc. 2010 Journal Article http://hdl.handle.net/20.500.11937/15281 10.1016/j.clim.2010.07.011 Academic Press restricted |
| spellingShingle | Lim, A. Allison, C. Price, Patricia Waterer, G. Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency |
| title | Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency |
| title_full | Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency |
| title_fullStr | Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency |
| title_full_unstemmed | Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency |
| title_short | Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency |
| title_sort | susceptibility to pulmonary disease due to mycobacterium avium-intracellulare complex may reflect low il-17 and high il-10 responses rather than th1 deficiency |
| url | http://hdl.handle.net/20.500.11937/15281 |