Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis
Two competing theories address the influence of foetal testosterone on cerebral laterality: one proposing exposure to high foetal testosterone concentrations is related to atypical lateralisation (Geschwind–Galaburda hypothesis), the other that high foetal testosterone concentrations exaggerate typi...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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Elsevier BV
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/15205 |
| _version_ | 1848748830656299008 |
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| author | Hollier, Lauren Maybery, M. Keelan, J. Hickey, M. Whitehouse, A. |
| author_facet | Hollier, Lauren Maybery, M. Keelan, J. Hickey, M. Whitehouse, A. |
| author_sort | Hollier, Lauren |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Two competing theories address the influence of foetal testosterone on cerebral laterality: one proposing exposure to high foetal testosterone concentrations is related to atypical lateralisation (Geschwind–Galaburda hypothesis), the other that high foetal testosterone concentrations exaggerate typical lateralisation (callosal hypothesis). The current study examined the relationship between cord testosterone concentrations and cerebral laterality for language and spatial memory in adulthood. Male participants with high (>0.15 nmol) and low (<0.10 nmol) cord testosterone levels were invited to take part in the study (n = 18 in each group). Cerebral laterality was measured using functional Transcranial Doppler ultrasonography, while participants completed word generation and visual short-term memory tasks. Typical left lateralisation of language was more common in the high-testosterone group than in the low-testosterone group, χ2 = 4.50, df = 1, p = 034. Spatial memory laterality was unrelated to cord testosterone level. Our findings indicate that foetal testosterone exposure is related to language laterality in a direction that supports the callosal hypothesis. |
| first_indexed | 2025-11-14T07:11:17Z |
| format | Journal Article |
| id | curtin-20.500.11937-15205 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:11:17Z |
| publishDate | 2014 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-152052017-09-13T15:04:45Z Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis Hollier, Lauren Maybery, M. Keelan, J. Hickey, M. Whitehouse, A. Cerebral laterality Foetal testosterone fTCD Language Raine study Visuospatial memory Two competing theories address the influence of foetal testosterone on cerebral laterality: one proposing exposure to high foetal testosterone concentrations is related to atypical lateralisation (Geschwind–Galaburda hypothesis), the other that high foetal testosterone concentrations exaggerate typical lateralisation (callosal hypothesis). The current study examined the relationship between cord testosterone concentrations and cerebral laterality for language and spatial memory in adulthood. Male participants with high (>0.15 nmol) and low (<0.10 nmol) cord testosterone levels were invited to take part in the study (n = 18 in each group). Cerebral laterality was measured using functional Transcranial Doppler ultrasonography, while participants completed word generation and visual short-term memory tasks. Typical left lateralisation of language was more common in the high-testosterone group than in the low-testosterone group, χ2 = 4.50, df = 1, p = 034. Spatial memory laterality was unrelated to cord testosterone level. Our findings indicate that foetal testosterone exposure is related to language laterality in a direction that supports the callosal hypothesis. 2014 Journal Article http://hdl.handle.net/20.500.11937/15205 10.1016/j.biopsycho.2014.08.009 Elsevier BV restricted |
| spellingShingle | Cerebral laterality Foetal testosterone fTCD Language Raine study Visuospatial memory Hollier, Lauren Maybery, M. Keelan, J. Hickey, M. Whitehouse, A. Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis |
| title | Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis |
| title_full | Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis |
| title_fullStr | Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis |
| title_full_unstemmed | Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis |
| title_short | Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis |
| title_sort | perinatal testosterone exposure and cerebral lateralisation in adult males: evidence for the callosal hypothesis |
| topic | Cerebral laterality Foetal testosterone fTCD Language Raine study Visuospatial memory |
| url | http://hdl.handle.net/20.500.11937/15205 |