Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease
This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson’s disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Geriatr...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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Public Library of Science
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/14975 |
| _version_ | 1848748767376834560 |
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| author | Lawrence, B. Gasson, Natalie Kane, Robert Bucks, R. Loftus, Andrea |
| author_facet | Lawrence, B. Gasson, Natalie Kane, Robert Bucks, R. Loftus, Andrea |
| author_sort | Lawrence, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson’s disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Geriatric Depression Scale (GDS-15), Parkinson’s Disease Questionnaire-39 (PDQ-39), and Unified Parkinson’s Disease Rating Scale-section 2 (UPDRS-section 2 [ADL]). Multiple Regression Analysis (MRA) was used to examine the mediator model. Depression and ADL significantly (p<.001) predicted HR-QOL, and depression significantly (p<.001) predicted ADL. Whilst ADL did not impact on the relationship between depression and HRQOL, there was a significant (p<.001) indirect effect of depression on HR-QOL via ADL, suggesting both direct and indirect (via ADL) effects of depression on HR-QOL. The magnitude of this effect was moderate (R2 = .13). People with PD who report depression also experience greater difficulty completing ADL, which impacts upon their HR-QOL. It is recommended that clinicians adopt a multidisciplinary approach to care by combining pharmacological treatments with psycho/occupational therapy, thereby alleviating the heterogeneous impact of motor and non-motor symptoms on HR-QOL in people with PD. |
| first_indexed | 2025-11-14T07:10:16Z |
| format | Journal Article |
| id | curtin-20.500.11937-14975 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:10:16Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-149752017-09-13T15:01:02Z Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease Lawrence, B. Gasson, Natalie Kane, Robert Bucks, R. Loftus, Andrea This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson’s disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Geriatric Depression Scale (GDS-15), Parkinson’s Disease Questionnaire-39 (PDQ-39), and Unified Parkinson’s Disease Rating Scale-section 2 (UPDRS-section 2 [ADL]). Multiple Regression Analysis (MRA) was used to examine the mediator model. Depression and ADL significantly (p<.001) predicted HR-QOL, and depression significantly (p<.001) predicted ADL. Whilst ADL did not impact on the relationship between depression and HRQOL, there was a significant (p<.001) indirect effect of depression on HR-QOL via ADL, suggesting both direct and indirect (via ADL) effects of depression on HR-QOL. The magnitude of this effect was moderate (R2 = .13). People with PD who report depression also experience greater difficulty completing ADL, which impacts upon their HR-QOL. It is recommended that clinicians adopt a multidisciplinary approach to care by combining pharmacological treatments with psycho/occupational therapy, thereby alleviating the heterogeneous impact of motor and non-motor symptoms on HR-QOL in people with PD. 2014 Journal Article http://hdl.handle.net/20.500.11937/14975 10.1371/journal.pone.0102294 Public Library of Science fulltext |
| spellingShingle | Lawrence, B. Gasson, Natalie Kane, Robert Bucks, R. Loftus, Andrea Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease |
| title | Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease |
| title_full | Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease |
| title_fullStr | Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease |
| title_full_unstemmed | Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease |
| title_short | Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease |
| title_sort | activities of daily living, depression, and quality of life in parkinson’s disease |
| url | http://hdl.handle.net/20.500.11937/14975 |