Rethinking phosphatidylinositol 3-monophosphate
A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that thi...
| Main Authors: | , |
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| Format: | Journal Article |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/14939 |
| _version_ | 1848748757197258752 |
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| author | Falasca, Marco Maffucci, T. |
| author_facet | Falasca, Marco Maffucci, T. |
| author_sort | Falasca, Marco |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second messenger involved in different physiological and pathological events and that specific intracellular localization of kinases and/or phosphatases is critical for PtdIns3P synthesis and PtdIns3P-dependent intracellular functions. Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years. © 2009 Elsevier B.V. All rights reserved. |
| first_indexed | 2025-11-14T07:10:07Z |
| format | Journal Article |
| id | curtin-20.500.11937-14939 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:10:07Z |
| publishDate | 2009 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-149392017-09-13T15:01:40Z Rethinking phosphatidylinositol 3-monophosphate Falasca, Marco Maffucci, T. A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second messenger involved in different physiological and pathological events and that specific intracellular localization of kinases and/or phosphatases is critical for PtdIns3P synthesis and PtdIns3P-dependent intracellular functions. Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years. © 2009 Elsevier B.V. All rights reserved. 2009 Journal Article http://hdl.handle.net/20.500.11937/14939 10.1016/j.bbamcr.2009.10.003 unknown |
| spellingShingle | Falasca, Marco Maffucci, T. Rethinking phosphatidylinositol 3-monophosphate |
| title | Rethinking phosphatidylinositol 3-monophosphate |
| title_full | Rethinking phosphatidylinositol 3-monophosphate |
| title_fullStr | Rethinking phosphatidylinositol 3-monophosphate |
| title_full_unstemmed | Rethinking phosphatidylinositol 3-monophosphate |
| title_short | Rethinking phosphatidylinositol 3-monophosphate |
| title_sort | rethinking phosphatidylinositol 3-monophosphate |
| url | http://hdl.handle.net/20.500.11937/14939 |