p53-targeted cancer pharmacotherapy: move towards small molecule compounds
Objectives For the past three decades of research, p53 has been identified as one of the most targetable molecules for developing anticancer treatments. This tumour suppressor protein is involved in apoptosis, cell cycle arrest and senescence. A wide range of pharmaceutical drugs and radiotherapy tr...
| Main Authors: | , |
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| Format: | Journal Article |
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John Wiley & Sons Ltd.
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/14671 |
| _version_ | 1848748685224050688 |
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| author | Kim, S. Dass, Crispin |
| author_facet | Kim, S. Dass, Crispin |
| author_sort | Kim, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives For the past three decades of research, p53 has been identified as one of the most targetable molecules for developing anticancer treatments. This tumour suppressor protein is involved in apoptosis, cell cycle arrest and senescence. A wide range of pharmaceutical drugs and radiotherapy treatments activate this protein and rely on p53 signalling for therapeutic outcome. Promising small molecular weight compounds, some of which are undergoing clinical trials, are discussed in this review. Key findings The spectrum of potential therapeutic approaches trialled for p53 stretch from gene therapy to the more recent development of small molecules capable of activating wild-type p53 or reactivating mutant p53. Summary Our ever-growing knowledge leads us to better understand this protein, from its structure and activities to its potential therapeutic application, firstly for cancer and then for other diseases and maybe even for reversal of ageing. |
| first_indexed | 2025-11-14T07:08:58Z |
| format | Journal Article |
| id | curtin-20.500.11937-14671 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:08:58Z |
| publishDate | 2011 |
| publisher | John Wiley & Sons Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-146712017-09-13T14:06:26Z p53-targeted cancer pharmacotherapy: move towards small molecule compounds Kim, S. Dass, Crispin Objectives For the past three decades of research, p53 has been identified as one of the most targetable molecules for developing anticancer treatments. This tumour suppressor protein is involved in apoptosis, cell cycle arrest and senescence. A wide range of pharmaceutical drugs and radiotherapy treatments activate this protein and rely on p53 signalling for therapeutic outcome. Promising small molecular weight compounds, some of which are undergoing clinical trials, are discussed in this review. Key findings The spectrum of potential therapeutic approaches trialled for p53 stretch from gene therapy to the more recent development of small molecules capable of activating wild-type p53 or reactivating mutant p53. Summary Our ever-growing knowledge leads us to better understand this protein, from its structure and activities to its potential therapeutic application, firstly for cancer and then for other diseases and maybe even for reversal of ageing. 2011 Journal Article http://hdl.handle.net/20.500.11937/14671 10.1111/j.2042-7158.2010.01248.x John Wiley & Sons Ltd. unknown |
| spellingShingle | Kim, S. Dass, Crispin p53-targeted cancer pharmacotherapy: move towards small molecule compounds |
| title | p53-targeted cancer pharmacotherapy: move towards small molecule compounds |
| title_full | p53-targeted cancer pharmacotherapy: move towards small molecule compounds |
| title_fullStr | p53-targeted cancer pharmacotherapy: move towards small molecule compounds |
| title_full_unstemmed | p53-targeted cancer pharmacotherapy: move towards small molecule compounds |
| title_short | p53-targeted cancer pharmacotherapy: move towards small molecule compounds |
| title_sort | p53-targeted cancer pharmacotherapy: move towards small molecule compounds |
| url | http://hdl.handle.net/20.500.11937/14671 |