The transcriptional landscape of age in human peripheral blood

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify...

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Main Authors:	Peters, M., Joehanes, R., Pilling, L., Schurmann, C., Conneely, K., Powell, J., Reinmaa, E., Sutphin, G., Zhernakova, A., Schramm, K., Wilson, Y., Kobes, S., Tukiainen, T., Ramos, Y., Göring, H., Fornage, M., Liu, Y., Gharib, S., Stranger, B., De Jager, P., Aviv, A., Levy, D., Murabito, J., Munson, P., Huan, T., Hofman, A., Uitterlinden, A., Rivadeneira, F., Van Rooij, J., Stolk, L., Broer, L., Verbiest, M., Jhamai, M., Arp, P., Metspalu, A., Tserel, L., Milani, L., Samani, N., Peterson, P., Kasela, S., Codd, V., Peters, A., Ward-Caviness, C., Herder, C., Waldenberger, M., Roden, M., Singmann, P., Zeilinger, S., Illig, T., Homuth, G., Grabe, H., Völzke, H., Steil, L., Kocher, T., Murray, A., Melzer, D., Yaghootkar, H., Bandinelli, S., Moses, Eric, Kent, J., Curran, J., Johnson, M., Williams-Blangero, S., Westra, H., McRae, A., Smith, J., Kardia, S., Hovatta, I., Perola, M., Ripatti, S., Salomaa, V., Henders, A.
Format:	Journal Article
Published:	2015
Online Access:	http://hdl.handle.net/20.500.11937/14537

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author	Peters, M. Joehanes, R. Pilling, L. Schurmann, C. Conneely, K. Powell, J. Reinmaa, E. Sutphin, G. Zhernakova, A. Schramm, K. Wilson, Y. Kobes, S. Tukiainen, T. Ramos, Y. Göring, H. Fornage, M. Liu, Y. Gharib, S. Stranger, B. De Jager, P. Aviv, A. Levy, D. Murabito, J. Munson, P. Huan, T. Hofman, A. Uitterlinden, A. Rivadeneira, F. Van Rooij, J. Stolk, L. Broer, L. Verbiest, M. Jhamai, M. Arp, P. Metspalu, A. Tserel, L. Milani, L. Samani, N. Peterson, P. Kasela, S. Codd, V. Peters, A. Ward-Caviness, C. Herder, C. Waldenberger, M. Roden, M. Singmann, P. Zeilinger, S. Illig, T. Homuth, G. Grabe, H. Völzke, H. Steil, L. Kocher, T. Murray, A. Melzer, D. Yaghootkar, H. Bandinelli, S. Moses, Eric Kent, J. Curran, J. Johnson, M. Williams-Blangero, S. Westra, H. McRae, A. Smith, J. Kardia, S. Hovatta, I. Perola, M. Ripatti, S. Salomaa, V. Henders, A.
author_facet	Peters, M. Joehanes, R. Pilling, L. Schurmann, C. Conneely, K. Powell, J. Reinmaa, E. Sutphin, G. Zhernakova, A. Schramm, K. Wilson, Y. Kobes, S. Tukiainen, T. Ramos, Y. Göring, H. Fornage, M. Liu, Y. Gharib, S. Stranger, B. De Jager, P. Aviv, A. Levy, D. Murabito, J. Munson, P. Huan, T. Hofman, A. Uitterlinden, A. Rivadeneira, F. Van Rooij, J. Stolk, L. Broer, L. Verbiest, M. Jhamai, M. Arp, P. Metspalu, A. Tserel, L. Milani, L. Samani, N. Peterson, P. Kasela, S. Codd, V. Peters, A. Ward-Caviness, C. Herder, C. Waldenberger, M. Roden, M. Singmann, P. Zeilinger, S. Illig, T. Homuth, G. Grabe, H. Völzke, H. Steil, L. Kocher, T. Murray, A. Melzer, D. Yaghootkar, H. Bandinelli, S. Moses, Eric Kent, J. Curran, J. Johnson, M. Williams-Blangero, S. Westra, H. McRae, A. Smith, J. Kardia, S. Hovatta, I. Perola, M. Ripatti, S. Salomaa, V. Henders, A.
author_sort	Peters, M.
building	Curtin Institutional Repository
collection	Online Access
description	Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the ‘transcriptomic age’ of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.
first_indexed	2025-11-14T07:08:24Z
format	Journal Article
id	curtin-20.500.11937-14537
institution	Curtin University Malaysia
institution_category	Local University
last_indexed	2025-11-14T07:08:24Z
publishDate	2015
recordtype	eprints
repository_type	Digital Repository
spelling	curtin-20.500.11937-145372017-09-13T14:05:39Z The transcriptional landscape of age in human peripheral blood Peters, M. Joehanes, R. Pilling, L. Schurmann, C. Conneely, K. Powell, J. Reinmaa, E. Sutphin, G. Zhernakova, A. Schramm, K. Wilson, Y. Kobes, S. Tukiainen, T. Ramos, Y. Göring, H. Fornage, M. Liu, Y. Gharib, S. Stranger, B. De Jager, P. Aviv, A. Levy, D. Murabito, J. Munson, P. Huan, T. Hofman, A. Uitterlinden, A. Rivadeneira, F. Van Rooij, J. Stolk, L. Broer, L. Verbiest, M. Jhamai, M. Arp, P. Metspalu, A. Tserel, L. Milani, L. Samani, N. Peterson, P. Kasela, S. Codd, V. Peters, A. Ward-Caviness, C. Herder, C. Waldenberger, M. Roden, M. Singmann, P. Zeilinger, S. Illig, T. Homuth, G. Grabe, H. Völzke, H. Steil, L. Kocher, T. Murray, A. Melzer, D. Yaghootkar, H. Bandinelli, S. Moses, Eric Kent, J. Curran, J. Johnson, M. Williams-Blangero, S. Westra, H. McRae, A. Smith, J. Kardia, S. Hovatta, I. Perola, M. Ripatti, S. Salomaa, V. Henders, A. Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the ‘transcriptomic age’ of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts. 2015 Journal Article http://hdl.handle.net/20.500.11937/14537 10.1038/ncomms9570 unknown
spellingShingle	Peters, M. Joehanes, R. Pilling, L. Schurmann, C. Conneely, K. Powell, J. Reinmaa, E. Sutphin, G. Zhernakova, A. Schramm, K. Wilson, Y. Kobes, S. Tukiainen, T. Ramos, Y. Göring, H. Fornage, M. Liu, Y. Gharib, S. Stranger, B. De Jager, P. Aviv, A. Levy, D. Murabito, J. Munson, P. Huan, T. Hofman, A. Uitterlinden, A. Rivadeneira, F. Van Rooij, J. Stolk, L. Broer, L. Verbiest, M. Jhamai, M. Arp, P. Metspalu, A. Tserel, L. Milani, L. Samani, N. Peterson, P. Kasela, S. Codd, V. Peters, A. Ward-Caviness, C. Herder, C. Waldenberger, M. Roden, M. Singmann, P. Zeilinger, S. Illig, T. Homuth, G. Grabe, H. Völzke, H. Steil, L. Kocher, T. Murray, A. Melzer, D. Yaghootkar, H. Bandinelli, S. Moses, Eric Kent, J. Curran, J. Johnson, M. Williams-Blangero, S. Westra, H. McRae, A. Smith, J. Kardia, S. Hovatta, I. Perola, M. Ripatti, S. Salomaa, V. Henders, A. The transcriptional landscape of age in human peripheral blood
title	The transcriptional landscape of age in human peripheral blood
title_full	The transcriptional landscape of age in human peripheral blood
title_fullStr	The transcriptional landscape of age in human peripheral blood
title_full_unstemmed	The transcriptional landscape of age in human peripheral blood
title_short	The transcriptional landscape of age in human peripheral blood
title_sort	transcriptional landscape of age in human peripheral blood
url	http://hdl.handle.net/20.500.11937/14537

The transcriptional landscape of age in human peripheral blood

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