Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

© 2015 Elsevier Masson SAS. Aggressive behavior and diffuse infiltrative growth are the main features of Glioblastoma multiforme (GBM), together with the high degree of resistance and recurrence. Evidence indicate that GBM-derived stem cells (GSCs), endowed with unlimited proliferative potential, pl...

Full description

Bibliographic Details
Main Authors: Sestito, S., Nesi, G., Daniele, S., Martelli, A., Digiacomo, M., Borghini, A., Pietra, D., Calderone, V., Lapucci, A., Falasca, Marco, Parrella, P., Notarangelo, A., Breschi, M., Macchia, M., Martini, C., Rapposelli, S.
Format: Journal Article
Published: 2015
Online Access:http://hdl.handle.net/20.500.11937/14246

Similar Items

Similar Items