TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians
Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previousl...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2013
|
| Online Access: | http://hdl.handle.net/20.500.11937/13961 |
| _version_ | 1848748490408067072 |
|---|---|
| author | Chew, C. Wadley, A. Lombard, Z. Kamerman, P. Price, Patricia |
| author_facet | Chew, C. Wadley, A. Lombard, Z. Kamerman, P. Price, Patricia |
| author_sort | Chew, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies. © 2013 Macmillan Publishers Limited. |
| first_indexed | 2025-11-14T07:05:52Z |
| format | Journal Article |
| id | curtin-20.500.11937-13961 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:05:52Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-139612017-09-13T15:02:44Z TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians Chew, C. Wadley, A. Lombard, Z. Kamerman, P. Price, Patricia Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies. © 2013 Macmillan Publishers Limited. 2013 Journal Article http://hdl.handle.net/20.500.11937/13961 10.1038/gene.2013.8 restricted |
| spellingShingle | Chew, C. Wadley, A. Lombard, Z. Kamerman, P. Price, Patricia TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians |
| title | TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians |
| title_full | TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians |
| title_fullStr | TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians |
| title_full_unstemmed | TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians |
| title_short | TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians |
| title_sort | tnf haplotypes in a southern african population resemble those seen in caucasians and asians |
| url | http://hdl.handle.net/20.500.11937/13961 |