Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.

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Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.

Mutations in hemochromatosis protein (HFE) or transferrin receptor 2 (TFR2) cause hereditary hemochromatosis (HH) by impeding production of the liver iron-regulatory hormone, hepcidin (HAMP). This study examined the effects of disruption of Hfe or Tfr2, either alone or together, on liver iron loadin...

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Bibliographic Details
Main Authors:	Delima, R., Chua, A., Tirnitz-Parker, Janina, Gan, E., Croft, K., Graham, Ross, Olynyk, John, Trinder, D.
Format:	Journal Article
Published:	John Wiley & Sons Inc. 2012
Online Access:	http://hdl.handle.net/20.500.11937/13843

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