Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioural development
Accurately measuring hormone exposure during prenatal life presents a methodological challenge and there is currently no “gold standard” approach. Ideally, circulating fetal hormone levels would be measured at repeated time points during pregnancy. However, it is not currently possible to obtain fet...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Frontiers Research Foundation
2014
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/13804 |
| _version_ | 1848748444323151872 |
|---|---|
| author | Hollier, Lauren Keelan, J. Hickey, M. Maybery, M. Whitehouse, A. |
| author_facet | Hollier, Lauren Keelan, J. Hickey, M. Maybery, M. Whitehouse, A. |
| author_sort | Hollier, Lauren |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Accurately measuring hormone exposure during prenatal life presents a methodological challenge and there is currently no “gold standard” approach. Ideally, circulating fetal hormone levels would be measured at repeated time points during pregnancy. However, it is not currently possible to obtain fetal blood samples without significant risk to the fetus, and therefore surrogate markers of fetal hormone levels must be utilized. Umbilical cord blood can be readily obtained at birth and largely reflects fetal circulation in late gestation.This review examines the accuracy and biological interpretation of the measurement of androgens and estrogens in cord blood. The use of cord blood hormones to understand and investigate human development is then discussed. |
| first_indexed | 2025-11-14T07:05:08Z |
| format | Journal Article |
| id | curtin-20.500.11937-13804 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:05:08Z |
| publishDate | 2014 |
| publisher | Frontiers Research Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-138042017-09-13T15:00:25Z Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioural development Hollier, Lauren Keelan, J. Hickey, M. Maybery, M. Whitehouse, A. prenatal androgens cord blood human development estrogens Accurately measuring hormone exposure during prenatal life presents a methodological challenge and there is currently no “gold standard” approach. Ideally, circulating fetal hormone levels would be measured at repeated time points during pregnancy. However, it is not currently possible to obtain fetal blood samples without significant risk to the fetus, and therefore surrogate markers of fetal hormone levels must be utilized. Umbilical cord blood can be readily obtained at birth and largely reflects fetal circulation in late gestation.This review examines the accuracy and biological interpretation of the measurement of androgens and estrogens in cord blood. The use of cord blood hormones to understand and investigate human development is then discussed. 2014 Journal Article http://hdl.handle.net/20.500.11937/13804 10.3389/fendo.2014.00064 Frontiers Research Foundation fulltext |
| spellingShingle | prenatal androgens cord blood human development estrogens Hollier, Lauren Keelan, J. Hickey, M. Maybery, M. Whitehouse, A. Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioural development |
| title | Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioural development |
| title_full | Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioural development |
| title_fullStr | Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioural development |
| title_full_unstemmed | Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioural development |
| title_short | Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioural development |
| title_sort | measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioural development |
| topic | prenatal androgens cord blood human development estrogens |
| url | http://hdl.handle.net/20.500.11937/13804 |