DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia
Although the advent of atypical, second-generation antipsychotics (SGAs) has resulted in reduced likelihood of akathisia, this adverse effect remains a problem. It is known that extrapyramidal adverse effects are associated with increased drug occupancy of the dopamine 2 receptors (DRD2). The A1 all...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
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Sage Publications
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/13792 |
| _version_ | 1848748441515065344 |
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| author | Lawford, B. Barnes, M. Swagell, C. Connor, J. Burton, S. Heslop, Karen Voisey, J. Morris, C. Nyst, P. Noble, E. Young, R. |
| author_facet | Lawford, B. Barnes, M. Swagell, C. Connor, J. Burton, S. Heslop, Karen Voisey, J. Morris, C. Nyst, P. Noble, E. Young, R. |
| author_sort | Lawford, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Although the advent of atypical, second-generation antipsychotics (SGAs) has resulted in reduced likelihood of akathisia, this adverse effect remains a problem. It is known that extrapyramidal adverse effects are associated with increased drug occupancy of the dopamine 2 receptors (DRD2). The A1 allele of the DRD2/ANKK1, rs1800497, is associated with decreased striatal DRD2 density. The aim of this study was to identify whether the A1(T) allele of DRD2/ANKK1 was associated with akathisia (as measured by Barnes Akathisia Rating Scale) in a clinical sample of 234 patients who were treated with antipsychotic drugs. Definite akathisia (a score ≥ 2 in the global clinical assessment of akathisia) was significantly less common in subjects who were prescribed SGAs (16.8%) than those prescribed FGAs (47.6%), p < 0.0001. Overall, 24.1% of A1+ patients (A1A2/A1A1) who were treated with SGAs had akathisia, compared to 10.8% of A1- (thus, A2A2) patients. A1+ patients who were administered SGAs also had higher global clinical assessment of akathisia scores than the A1- subjects (p = 0.01). SGAs maintained their advantage over FGAs regarding akathisia, even in A1+ patients who were treated with SGAs. These results strongly suggested that A1+ variants of the DRD2/ANKK1 Taq1A allele do confer an associated risk for akathisia in patients who were treated with SGAs, and these variants may explain inconsistencies found across prior studies, when comparing FGAs and SGAs. |
| first_indexed | 2025-11-14T07:05:06Z |
| format | Journal Article |
| id | curtin-20.500.11937-13792 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:05:06Z |
| publishDate | 2013 |
| publisher | Sage Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-137922018-03-29T09:06:09Z DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia Lawford, B. Barnes, M. Swagell, C. Connor, J. Burton, S. Heslop, Karen Voisey, J. Morris, C. Nyst, P. Noble, E. Young, R. ANNK1 side effects drug types Akathisia genetic association antipsychotic drugs dopamine 2 receptor Although the advent of atypical, second-generation antipsychotics (SGAs) has resulted in reduced likelihood of akathisia, this adverse effect remains a problem. It is known that extrapyramidal adverse effects are associated with increased drug occupancy of the dopamine 2 receptors (DRD2). The A1 allele of the DRD2/ANKK1, rs1800497, is associated with decreased striatal DRD2 density. The aim of this study was to identify whether the A1(T) allele of DRD2/ANKK1 was associated with akathisia (as measured by Barnes Akathisia Rating Scale) in a clinical sample of 234 patients who were treated with antipsychotic drugs. Definite akathisia (a score ≥ 2 in the global clinical assessment of akathisia) was significantly less common in subjects who were prescribed SGAs (16.8%) than those prescribed FGAs (47.6%), p < 0.0001. Overall, 24.1% of A1+ patients (A1A2/A1A1) who were treated with SGAs had akathisia, compared to 10.8% of A1- (thus, A2A2) patients. A1+ patients who were administered SGAs also had higher global clinical assessment of akathisia scores than the A1- subjects (p = 0.01). SGAs maintained their advantage over FGAs regarding akathisia, even in A1+ patients who were treated with SGAs. These results strongly suggested that A1+ variants of the DRD2/ANKK1 Taq1A allele do confer an associated risk for akathisia in patients who were treated with SGAs, and these variants may explain inconsistencies found across prior studies, when comparing FGAs and SGAs. 2013 Journal Article http://hdl.handle.net/20.500.11937/13792 10.1177/0269881112463469 Sage Publications restricted |
| spellingShingle | ANNK1 side effects drug types Akathisia genetic association antipsychotic drugs dopamine 2 receptor Lawford, B. Barnes, M. Swagell, C. Connor, J. Burton, S. Heslop, Karen Voisey, J. Morris, C. Nyst, P. Noble, E. Young, R. DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia |
| title | DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia |
| title_full | DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia |
| title_fullStr | DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia |
| title_full_unstemmed | DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia |
| title_short | DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia |
| title_sort | drd2/ankk1 taq1a (rs 1800497 c>t) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia |
| topic | ANNK1 side effects drug types Akathisia genetic association antipsychotic drugs dopamine 2 receptor |
| url | http://hdl.handle.net/20.500.11937/13792 |