Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours

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Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours

The DNA enzyme Dz13, targeted against the oncogene c-Jun, is capable of inhibiting various model tumours in mice albeit in ectopic models of neoplasia. In previous studies using orthotopic models of disease, the inhibitory effects of Dz13 on secondary growth was a direct result of growth inhibition...

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Bibliographic Details
Main Authors:	Tan, M., Choong, P., Dass, Crispin
Format:	Journal Article
Published:	BioMed Central Ltd 2010
Online Access:	http://hdl.handle.net/20.500.11937/13165

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