In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland

In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland

We investigated the metabolism of vitamin D2 to hydroxyvitamin D2 metabolites ((OH)D2) by human placentas ex-utero, adrenal glands ex-vivo and cultured human epidermal keratinocytes and colonic Caco-2 cells, and identified 20(OH)D2, 17,20(OH)2D2, 1,20(OH)2D2, 25(OH)D2 and 1,25(OH)2D2 as products. In...

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Bibliographic Details
Main Authors: Slominski, A., Kim, T., Shehabi, Haleem, Tang, E., Benson, Heather, Semak, I., Lin, Z., Yates, C., Wang, J., Li, W., Tuckey, R.
Format: Journal Article
Published: Elsevier Ireland Ltd 2014
Subjects:
20-Hydroxyvitmin D2
Vitamin D
CYP11A1
Placenta
Adrenals
Keratinocytes
Online Access:http://hdl.handle.net/20.500.11937/13006

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