Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer
The balance of endogenous angiogenic factors in the body is responsible for the homeostatic control of angiogenesis during normal physiological circumstances, with the disruption of this fragile balance leading to pathologic angiogenic events such as those involved in cancer progression. This review...
| Main Authors: | , |
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| Format: | Journal Article |
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S. Karger AG
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/12981 |
| _version_ | 1848748226295889920 |
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| author | Alcantara, M. Dass, Crispin |
| author_facet | Alcantara, M. Dass, Crispin |
| author_sort | Alcantara, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The balance of endogenous angiogenic factors in the body is responsible for the homeostatic control of angiogenesis during normal physiological circumstances, with the disruption of this fragile balance leading to pathologic angiogenic events such as those involved in cancer progression. This review focuses regulation of the pro-angiogenic factors membrane type-1 matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) by the antiangiogenic factor pigment epithelium-derived factor (PEDF) in the contexts of angiogenesis, cancer cell proliferation and metastasis. Understanding the role of PEDF in the regulation of MT1-MMP and MMP-2 as it pertains to cancer control is important in order to understand whether and how such associations provide a novel target for cancer therapy |
| first_indexed | 2025-11-14T07:01:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-12981 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:01:40Z |
| publishDate | 2013 |
| publisher | S. Karger AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-129812017-09-13T15:00:24Z Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer Alcantara, M. Dass, Crispin The balance of endogenous angiogenic factors in the body is responsible for the homeostatic control of angiogenesis during normal physiological circumstances, with the disruption of this fragile balance leading to pathologic angiogenic events such as those involved in cancer progression. This review focuses regulation of the pro-angiogenic factors membrane type-1 matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) by the antiangiogenic factor pigment epithelium-derived factor (PEDF) in the contexts of angiogenesis, cancer cell proliferation and metastasis. Understanding the role of PEDF in the regulation of MT1-MMP and MMP-2 as it pertains to cancer control is important in order to understand whether and how such associations provide a novel target for cancer therapy 2013 Journal Article http://hdl.handle.net/20.500.11937/12981 10.1159/000350069 S. Karger AG unknown |
| spellingShingle | Alcantara, M. Dass, Crispin Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer |
| title | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer |
| title_full | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer |
| title_fullStr | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer |
| title_full_unstemmed | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer |
| title_short | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer |
| title_sort | regulation of mt1-mmp and mmp-2 by the serpin pedf: a promising new target for metastatic cancer |
| url | http://hdl.handle.net/20.500.11937/12981 |