High-Dose Thiamine Supplementation Improves Glucose Tolerance in Hyperglycemic Individuals: a Randomized, Double-Blind Cross-Over Trial
Purpose: To assess the effect of high-dose oral thiamine supplements on glucose tolerance in patients with impaired glucose metabolism. Methods: Twelve hyperglycemic subjects (10 cases of impaired glucose tolerance and 2 new cases of type 2 diabetes) completed this randomized, double-blind trial, wh...
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| Format: | Journal Article |
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Springer Medizin
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/12960 |
| _version_ | 1848748220682862592 |
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| author | Shahmiri, F. Soares, Mario Zhao, Y. Sherriff, Jillian |
| author_facet | Shahmiri, F. Soares, Mario Zhao, Y. Sherriff, Jillian |
| author_sort | Shahmiri, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose: To assess the effect of high-dose oral thiamine supplements on glucose tolerance in patients with impaired glucose metabolism. Methods: Twelve hyperglycemic subjects (10 cases of impaired glucose tolerance and 2 new cases of type 2 diabetes) completed this randomized, double-blind trial, where all participants received both placebo and thiamine capsules (3 × 100 mg/day) for 6 weeks in a cross-over manner. The main endpoint was changes in 2-h plasma glucose. Fasting plasma glucose and insulin, 2-h plasma insulin, the hemostatic model assessment of insulin resistance (HOMA-IR), renal function measurement and thiamin status were also evaluated at the commencement and completion of each treatment period. Results: Thiamine supplementation resulted in significant decrease in 2-h plasma glucose relative to baseline (8.78 ± 2.20 vs. 9.89 ± 2.50 mmol/l, p = 0.004), with no significant change in the placebo arm. Fasting plasma glucose and insulin, and HOMA-IR increased significantly from baseline after 6 weeks in the placebo arm (p = 0.003, p = 0.04 and p = 0.02, respectively). These variables did not change with thiamine supplementation. There were no significant changes in 2-h plasma insulin or renal function marker, within or between arms. Conclusion/interpretation: Supplementation with high-dose thiamine may prevent deterioration in fasting glucose and insulin, and improve glucose tolerance in patients with hyperglycemia. High-dose thiamine supplementation may prevent or slow the progression of hyperglycemia toward diabetes mellitus in individuals with impaired glucose regulation. |
| first_indexed | 2025-11-14T07:01:35Z |
| format | Journal Article |
| id | curtin-20.500.11937-12960 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:01:35Z |
| publishDate | 2013 |
| publisher | Springer Medizin |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-129602019-02-19T05:34:47Z High-Dose Thiamine Supplementation Improves Glucose Tolerance in Hyperglycemic Individuals: a Randomized, Double-Blind Cross-Over Trial Shahmiri, F. Soares, Mario Zhao, Y. Sherriff, Jillian Hyperglycemia Thiamine Type 2 diabetes Glucose tolerance Insulin resistance Cardiovascular disease Purpose: To assess the effect of high-dose oral thiamine supplements on glucose tolerance in patients with impaired glucose metabolism. Methods: Twelve hyperglycemic subjects (10 cases of impaired glucose tolerance and 2 new cases of type 2 diabetes) completed this randomized, double-blind trial, where all participants received both placebo and thiamine capsules (3 × 100 mg/day) for 6 weeks in a cross-over manner. The main endpoint was changes in 2-h plasma glucose. Fasting plasma glucose and insulin, 2-h plasma insulin, the hemostatic model assessment of insulin resistance (HOMA-IR), renal function measurement and thiamin status were also evaluated at the commencement and completion of each treatment period. Results: Thiamine supplementation resulted in significant decrease in 2-h plasma glucose relative to baseline (8.78 ± 2.20 vs. 9.89 ± 2.50 mmol/l, p = 0.004), with no significant change in the placebo arm. Fasting plasma glucose and insulin, and HOMA-IR increased significantly from baseline after 6 weeks in the placebo arm (p = 0.003, p = 0.04 and p = 0.02, respectively). These variables did not change with thiamine supplementation. There were no significant changes in 2-h plasma insulin or renal function marker, within or between arms. Conclusion/interpretation: Supplementation with high-dose thiamine may prevent deterioration in fasting glucose and insulin, and improve glucose tolerance in patients with hyperglycemia. High-dose thiamine supplementation may prevent or slow the progression of hyperglycemia toward diabetes mellitus in individuals with impaired glucose regulation. 2013 Journal Article http://hdl.handle.net/20.500.11937/12960 10.1007/s00394-013-0534-6 Springer Medizin fulltext |
| spellingShingle | Hyperglycemia Thiamine Type 2 diabetes Glucose tolerance Insulin resistance Cardiovascular disease Shahmiri, F. Soares, Mario Zhao, Y. Sherriff, Jillian High-Dose Thiamine Supplementation Improves Glucose Tolerance in Hyperglycemic Individuals: a Randomized, Double-Blind Cross-Over Trial |
| title | High-Dose Thiamine Supplementation Improves Glucose Tolerance in Hyperglycemic Individuals: a Randomized, Double-Blind Cross-Over Trial |
| title_full | High-Dose Thiamine Supplementation Improves Glucose Tolerance in Hyperglycemic Individuals: a Randomized, Double-Blind Cross-Over Trial |
| title_fullStr | High-Dose Thiamine Supplementation Improves Glucose Tolerance in Hyperglycemic Individuals: a Randomized, Double-Blind Cross-Over Trial |
| title_full_unstemmed | High-Dose Thiamine Supplementation Improves Glucose Tolerance in Hyperglycemic Individuals: a Randomized, Double-Blind Cross-Over Trial |
| title_short | High-Dose Thiamine Supplementation Improves Glucose Tolerance in Hyperglycemic Individuals: a Randomized, Double-Blind Cross-Over Trial |
| title_sort | high-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial |
| topic | Hyperglycemia Thiamine Type 2 diabetes Glucose tolerance Insulin resistance Cardiovascular disease |
| url | http://hdl.handle.net/20.500.11937/12960 |