NF-κB in cancer therapy
The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family membe...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Springer Verlag
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/12782 |
| _version_ | 1848748172843679744 |
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| author | Li, F. Zhang, J. Arfuso, Frank Chinnathambi, A. Zayed, M. Alharbi, S. Kumar, Alan Prem Ahn, K. Sethi, G. |
| author_facet | Li, F. Zhang, J. Arfuso, Frank Chinnathambi, A. Zayed, M. Alharbi, S. Kumar, Alan Prem Ahn, K. Sethi, G. |
| author_sort | Li, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regulated genes have been linked to malignant transformation, tumor cell proliferation, survival, angiogenesis, invasion/metastasis, and therapeutic resistance. In this review, we highlight the diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. Additionally, various pharmacological approaches employed to target the deregulated NF-κB signaling pathway, and their possible therapeutic potential in cancer therapy is also discussed briefly. |
| first_indexed | 2025-11-14T07:00:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-12782 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:00:49Z |
| publishDate | 2015 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-127822017-09-13T15:02:13Z NF-κB in cancer therapy Li, F. Zhang, J. Arfuso, Frank Chinnathambi, A. Zayed, M. Alharbi, S. Kumar, Alan Prem Ahn, K. Sethi, G. The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regulated genes have been linked to malignant transformation, tumor cell proliferation, survival, angiogenesis, invasion/metastasis, and therapeutic resistance. In this review, we highlight the diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. Additionally, various pharmacological approaches employed to target the deregulated NF-κB signaling pathway, and their possible therapeutic potential in cancer therapy is also discussed briefly. 2015 Journal Article http://hdl.handle.net/20.500.11937/12782 10.1007/s00204-015-1470-4 Springer Verlag restricted |
| spellingShingle | Li, F. Zhang, J. Arfuso, Frank Chinnathambi, A. Zayed, M. Alharbi, S. Kumar, Alan Prem Ahn, K. Sethi, G. NF-κB in cancer therapy |
| title | NF-κB in cancer therapy |
| title_full | NF-κB in cancer therapy |
| title_fullStr | NF-κB in cancer therapy |
| title_full_unstemmed | NF-κB in cancer therapy |
| title_short | NF-κB in cancer therapy |
| title_sort | nf-κb in cancer therapy |
| url | http://hdl.handle.net/20.500.11937/12782 |