Release of Bioactive Molecules Using Metal Complexes
The biological activity of molecules is modulated by coordination to a transition metal centre. Ideally, this results in a completely inactive system, which acts as a prodrug, from which the bioactive component can be released by a specific trigger mechanism in a spatially and temporally controlled...
| Main Authors: | , |
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| Format: | Book Chapter |
| Published: |
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/12699 |
| _version_ | 1848748150009888768 |
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| author | Simpson, Peter Schatzschneider, U. |
| author_facet | Simpson, Peter Schatzschneider, U. |
| author_sort | Simpson, Peter |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The biological activity of molecules is modulated by coordination to a transition metal centre. Ideally, this results in a completely inactive system, which acts as a prodrug, from which the bioactive component can be released by a specific trigger mechanism in a spatially and temporally controlled way. This chapter focuses on three different applications, to highlight general concepts as well as current challenges in the area: (1) the release of small-molecule messengers such as nitric oxide (NO) and carbon monoxide (CO) from the metal coordination sphere; (2) the "photouncaging" of organic neurotransmitters from metal complexes; and (3) the hypoxia-activated release of anticancer-active compounds from metal-based prodrugs. |
| first_indexed | 2025-11-14T07:00:28Z |
| format | Book Chapter |
| id | curtin-20.500.11937-12699 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:00:28Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-126992017-09-13T15:00:24Z Release of Bioactive Molecules Using Metal Complexes Simpson, Peter Schatzschneider, U. The biological activity of molecules is modulated by coordination to a transition metal centre. Ideally, this results in a completely inactive system, which acts as a prodrug, from which the bioactive component can be released by a specific trigger mechanism in a spatially and temporally controlled way. This chapter focuses on three different applications, to highlight general concepts as well as current challenges in the area: (1) the release of small-molecule messengers such as nitric oxide (NO) and carbon monoxide (CO) from the metal coordination sphere; (2) the "photouncaging" of organic neurotransmitters from metal complexes; and (3) the hypoxia-activated release of anticancer-active compounds from metal-based prodrugs. 2014 Book Chapter http://hdl.handle.net/20.500.11937/12699 10.1002/9781118682975.ch10 restricted |
| spellingShingle | Simpson, Peter Schatzschneider, U. Release of Bioactive Molecules Using Metal Complexes |
| title | Release of Bioactive Molecules Using Metal Complexes |
| title_full | Release of Bioactive Molecules Using Metal Complexes |
| title_fullStr | Release of Bioactive Molecules Using Metal Complexes |
| title_full_unstemmed | Release of Bioactive Molecules Using Metal Complexes |
| title_short | Release of Bioactive Molecules Using Metal Complexes |
| title_sort | release of bioactive molecules using metal complexes |
| url | http://hdl.handle.net/20.500.11937/12699 |