Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery
In this work a novel strategy has been developed to prepare well-dispersed amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposite (NH2-SiO2@LDH) via electrostatic interactions and condensation of (3-aminopropyl)triethoxysilane (APTES). This nanocomposite system is well dispe...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Tsinghua University Press
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/12574 |
| _version_ | 1848748111929802752 |
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| author | Li, L. Gu, W. Liu, Jian Yan, S. Xu, Z. |
| author_facet | Li, L. Gu, W. Liu, Jian Yan, S. Xu, Z. |
| author_sort | Li, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In this work a novel strategy has been developed to prepare well-dispersed amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposite (NH2-SiO2@LDH) via electrostatic interactions and condensation of (3-aminopropyl)triethoxysilane (APTES). This nanocomposite system is well dispersed in culture media and phosphate buffered saline, and exhibits low cytotoxicity and good biocompatibility. The fluorescence microscopy images and flow cytometry data indicate that such an NH2-SiO2@LDH nanocomposite is able to efficiently deliver small interfering RNA (siRNA) into the U2OS cell line to inhibit cell proliferation. Thus, NH2-SiO2@LDH nanocomposite has a great potential as a nanocarrier for efficient gene delivery. |
| first_indexed | 2025-11-14T06:59:51Z |
| format | Journal Article |
| id | curtin-20.500.11937-12574 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:59:51Z |
| publishDate | 2015 |
| publisher | Tsinghua University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-125742017-09-13T14:56:52Z Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery Li, L. Gu, W. Liu, Jian Yan, S. Xu, Z. In this work a novel strategy has been developed to prepare well-dispersed amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposite (NH2-SiO2@LDH) via electrostatic interactions and condensation of (3-aminopropyl)triethoxysilane (APTES). This nanocomposite system is well dispersed in culture media and phosphate buffered saline, and exhibits low cytotoxicity and good biocompatibility. The fluorescence microscopy images and flow cytometry data indicate that such an NH2-SiO2@LDH nanocomposite is able to efficiently deliver small interfering RNA (siRNA) into the U2OS cell line to inhibit cell proliferation. Thus, NH2-SiO2@LDH nanocomposite has a great potential as a nanocarrier for efficient gene delivery. 2015 Journal Article http://hdl.handle.net/20.500.11937/12574 10.1007/s12274-014-0552-6 Tsinghua University Press restricted |
| spellingShingle | Li, L. Gu, W. Liu, Jian Yan, S. Xu, Z. Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery |
| title | Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery |
| title_full | Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery |
| title_fullStr | Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery |
| title_full_unstemmed | Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery |
| title_short | Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery |
| title_sort | amine-functionalized sio2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery |
| url | http://hdl.handle.net/20.500.11937/12574 |