P2X purinergic receptor ligands: recently patented compounds
Importance of the field: P2X channels are ionotropic purinergic receptors that are currently under scrutiny as attractive targets for novel therapeutics in areas including chronic inflammation, pain and depression. Their wide expression in the CNS, recent advances in the biochemical and pharmacologi...
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| Format: | Journal Article |
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Informa Healthcare
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/12546 |
| _version_ | 1848748104852963328 |
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| author | Gunosewoyo, Hendra Kassiou, M. |
| author_facet | Gunosewoyo, Hendra Kassiou, M. |
| author_sort | Gunosewoyo, Hendra |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Importance of the field: P2X channels are ionotropic purinergic receptors that are currently under scrutiny as attractive targets for novel therapeutics in areas including chronic inflammation, pain and depression. Their wide expression in the CNS, recent advances in the biochemical and pharmacological properties as well as increasing numbers of patents published in this research domain demand a review in this field. Areas covered in this review: The patent literature covering novel drug-like antagonists for each P2X receptor subtype (P2X1R to P2X7R) up to December 2009 is described in this review article together with their recent highlights in pharmacology. What the reader will gain: Readers will gain an up-to-date overview of patents covering drug-like antagonists for seven P2X receptor subtypes within the last 4 years. Take home message: P2X7R antagonists and other P2X inhibitors will probably be on the market for combating rheumatoid arthritis and other diseases. Some P2X7R antagonists are already in Phase I and II clinical trials. |
| first_indexed | 2025-11-14T06:59:45Z |
| format | Journal Article |
| id | curtin-20.500.11937-12546 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:59:45Z |
| publishDate | 2010 |
| publisher | Informa Healthcare |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-125462017-09-13T14:58:13Z P2X purinergic receptor ligands: recently patented compounds Gunosewoyo, Hendra Kassiou, M. purinergic theraputic applications P2X drug discovery Importance of the field: P2X channels are ionotropic purinergic receptors that are currently under scrutiny as attractive targets for novel therapeutics in areas including chronic inflammation, pain and depression. Their wide expression in the CNS, recent advances in the biochemical and pharmacological properties as well as increasing numbers of patents published in this research domain demand a review in this field. Areas covered in this review: The patent literature covering novel drug-like antagonists for each P2X receptor subtype (P2X1R to P2X7R) up to December 2009 is described in this review article together with their recent highlights in pharmacology. What the reader will gain: Readers will gain an up-to-date overview of patents covering drug-like antagonists for seven P2X receptor subtypes within the last 4 years. Take home message: P2X7R antagonists and other P2X inhibitors will probably be on the market for combating rheumatoid arthritis and other diseases. Some P2X7R antagonists are already in Phase I and II clinical trials. 2010 Journal Article http://hdl.handle.net/20.500.11937/12546 10.1517/13543771003702424 Informa Healthcare restricted |
| spellingShingle | purinergic theraputic applications P2X drug discovery Gunosewoyo, Hendra Kassiou, M. P2X purinergic receptor ligands: recently patented compounds |
| title | P2X purinergic receptor ligands: recently patented compounds |
| title_full | P2X purinergic receptor ligands: recently patented compounds |
| title_fullStr | P2X purinergic receptor ligands: recently patented compounds |
| title_full_unstemmed | P2X purinergic receptor ligands: recently patented compounds |
| title_short | P2X purinergic receptor ligands: recently patented compounds |
| title_sort | p2x purinergic receptor ligands: recently patented compounds |
| topic | purinergic theraputic applications P2X drug discovery |
| url | http://hdl.handle.net/20.500.11937/12546 |