The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia
Objectives: Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods: DNA from ADC patients (n = 56), unselected HIV-seropositive patients (n = 112, 171, 185 and 204) and HIV-seronegative controls (n = 204, 60, 60, 96 and 624) were typed for polymorphic loci in genes enco...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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Blackwell Publishing Ltd
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/12464 |
| _version_ | 1848748083759808512 |
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| author | Pemberton, L. Stone, E. Price, Patricia Van Bockxmeer, F. Brew, B. |
| author_facet | Pemberton, L. Stone, E. Price, Patricia Van Bockxmeer, F. Brew, B. |
| author_sort | Pemberton, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods: DNA from ADC patients (n = 56), unselected HIV-seropositive patients (n = 112, 171, 185 and 204) and HIV-seronegative controls (n = 204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-a, interleukin (IL)-1a, IL-1ß, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage =1 and CD4 counts of <500 cells/µL. Results: Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P = 0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results. Conclusions: This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC. © 2008 British HIV Association. |
| first_indexed | 2025-11-14T06:59:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-12464 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:59:24Z |
| publishDate | 2008 |
| publisher | Blackwell Publishing Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-124642017-09-13T14:58:12Z The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia Pemberton, L. Stone, E. Price, Patricia Van Bockxmeer, F. Brew, B. Objectives: Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods: DNA from ADC patients (n = 56), unselected HIV-seropositive patients (n = 112, 171, 185 and 204) and HIV-seronegative controls (n = 204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-a, interleukin (IL)-1a, IL-1ß, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage =1 and CD4 counts of <500 cells/µL. Results: Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P = 0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results. Conclusions: This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC. © 2008 British HIV Association. 2008 Journal Article http://hdl.handle.net/20.500.11937/12464 10.1111/j.1468-1293.2008.00614.x Blackwell Publishing Ltd unknown |
| spellingShingle | Pemberton, L. Stone, E. Price, Patricia Van Bockxmeer, F. Brew, B. The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia |
| title | The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia |
| title_full | The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia |
| title_fullStr | The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia |
| title_full_unstemmed | The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia |
| title_short | The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia |
| title_sort | relationship between apoe, tnfa, il1a, il1b and il12b genes and hiv-1-associated dementia |
| url | http://hdl.handle.net/20.500.11937/12464 |