Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors
The objectives of our study were to examine 1) the proportion of responders and nonresponders to exercise training in terms of vascular function; 2) a priori factors related to exercise training-induced changes in conduit artery function, and 3) the contribution of traditional cardiovascular risk fa...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
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The American Physiological Society
2014
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/12271 |
| _version_ | 1848748031174770688 |
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| author | Green, D. Eijsvogels, T. Bouts, Y. Maiorana, Andrew Naylor, L. Scholten, R. Spaanderman, M. Pugh, C. Sprung, V. Schreuder, T. Jones, H. Cable, N.T. Cable, N.T. Hopman, M. Thijssen, D. |
| author_facet | Green, D. Eijsvogels, T. Bouts, Y. Maiorana, Andrew Naylor, L. Scholten, R. Spaanderman, M. Pugh, C. Sprung, V. Schreuder, T. Jones, H. Cable, N.T. Cable, N.T. Hopman, M. Thijssen, D. |
| author_sort | Green, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The objectives of our study were to examine 1) the proportion of responders and nonresponders to exercise training in terms of vascular function; 2) a priori factors related to exercise training-induced changes in conduit artery function, and 3) the contribution of traditional cardiovascular risk factors to exercise-induced changes in artery function. We pooled data from our laboratories involving 182 subjects who underwent supervised, large-muscle group, endurance-type exercise training interventions with pre-/posttraining measures of flow-mediated dilation (FMD%) to assess artery function. All studies adopted an identical FMD protocol (5-min ischemia, distal cuff inflation), contemporary echo-Doppler methodology, and observer-independent automated analysis. Linear regression analysis was used to identify factors contributing to changes in FMD%. We found that cardiopulmonary fitness improved, and weight, body mass index (BMI), cholesterol, and mean arterial pressure (MAP) decreased after training, while FMD% increased in 76% of subjects (P < 0.001). Training-induced increase in FMD% was predicted by lower body weight (β = −0.212), lower baseline FMD% (β = −0.469), lower training frequency (β = −0.256), and longer training duration (β = 0.367) (combined: P < 0.001, r = 0.63). With the exception of a modest correlation with total cholesterol (r = −0.243, P < 0.01), changes in traditional cardiovascular risk factors were not significantly related to changes in FMD% (P > 0.05).In conclusion, we found that, while some subjects do not demonstrate increases following exercise training, improvement in FMD% is present in those with lower pretraining body weight and endothelial function. Moreover, exercise training-induced change in FMD% did not correlate with changes in traditional cardiovascular risk factors, indicating that some cardioprotective effects of exercise training are independent of improvement in risk factors. |
| first_indexed | 2025-11-14T06:58:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-12271 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:58:34Z |
| publishDate | 2014 |
| publisher | The American Physiological Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-122712023-02-22T06:24:20Z Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors Green, D. Eijsvogels, T. Bouts, Y. Maiorana, Andrew Naylor, L. Scholten, R. Spaanderman, M. Pugh, C. Sprung, V. Schreuder, T. Jones, H. Cable, N.T. Cable, N.T. Hopman, M. Thijssen, D. endothelial function nitric oxide physical activity flow-mediated dilation cardiovascular risk The objectives of our study were to examine 1) the proportion of responders and nonresponders to exercise training in terms of vascular function; 2) a priori factors related to exercise training-induced changes in conduit artery function, and 3) the contribution of traditional cardiovascular risk factors to exercise-induced changes in artery function. We pooled data from our laboratories involving 182 subjects who underwent supervised, large-muscle group, endurance-type exercise training interventions with pre-/posttraining measures of flow-mediated dilation (FMD%) to assess artery function. All studies adopted an identical FMD protocol (5-min ischemia, distal cuff inflation), contemporary echo-Doppler methodology, and observer-independent automated analysis. Linear regression analysis was used to identify factors contributing to changes in FMD%. We found that cardiopulmonary fitness improved, and weight, body mass index (BMI), cholesterol, and mean arterial pressure (MAP) decreased after training, while FMD% increased in 76% of subjects (P < 0.001). Training-induced increase in FMD% was predicted by lower body weight (β = −0.212), lower baseline FMD% (β = −0.469), lower training frequency (β = −0.256), and longer training duration (β = 0.367) (combined: P < 0.001, r = 0.63). With the exception of a modest correlation with total cholesterol (r = −0.243, P < 0.01), changes in traditional cardiovascular risk factors were not significantly related to changes in FMD% (P > 0.05).In conclusion, we found that, while some subjects do not demonstrate increases following exercise training, improvement in FMD% is present in those with lower pretraining body weight and endothelial function. Moreover, exercise training-induced change in FMD% did not correlate with changes in traditional cardiovascular risk factors, indicating that some cardioprotective effects of exercise training are independent of improvement in risk factors. 2014 Journal Article http://hdl.handle.net/20.500.11937/12271 10.1152/japplphysiol.00354.2014 The American Physiological Society unknown |
| spellingShingle | endothelial function nitric oxide physical activity flow-mediated dilation cardiovascular risk Green, D. Eijsvogels, T. Bouts, Y. Maiorana, Andrew Naylor, L. Scholten, R. Spaanderman, M. Pugh, C. Sprung, V. Schreuder, T. Jones, H. Cable, N.T. Cable, N.T. Hopman, M. Thijssen, D. Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors |
| title | Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors |
| title_full | Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors |
| title_fullStr | Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors |
| title_full_unstemmed | Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors |
| title_short | Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors |
| title_sort | exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors |
| topic | endothelial function nitric oxide physical activity flow-mediated dilation cardiovascular risk |
| url | http://hdl.handle.net/20.500.11937/12271 |