Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further t...

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Main Authors:	Law, M., Bishop, D., Lee, J., Brossard, M., Martin, N., Moses, Eric, Song, F., Barrett, J., Kumar, R., Easton, D., Pharoah, P., Swerdlow, A., Kypreou, K., Taylor, J., Harland, M., Randerson-Moor, J., Akslen, L., Andresen, P., Avril, M., Azizi, E., Scarrà, G., Brown, K., Debniak, T., Duffy, D., Elder, D., Fang, S., Friedman, E., Galan, P., Ghiorzo, P., Gillanders, E., Goldstein, A., Gruis, N., Hansson, J., Helsing, P., Hocevar, M., Höiom, V., Ingvar, C., Kanetsky, P., Chen, W., Landi, M., Lang, J., Lathrop, G., Lubinski, J., MacKie, R., Mann, G., Molven, A., Montgomery, G., Novakovic, S., Olsson, H., Puig, S., Puig-Butille, J., Qureshi, A., Radford-Smith, G., Van Der Stoep, N., Van Doorn, R., Whiteman, D., Craig, J., Schadendorf, D., Simms, L., Burdon, K., Nyholt, D., Pooley, K., Orr, N., Stratigos, A., Cust, A., Ward, S., Hayward, N., Han, J., Schulze, H., Dunning, A., Bishop, J., Demenais, F., Amos, C., MacGregor, S., Iles, M.
Format:	Journal Article
Published:	2015
Online Access:	http://hdl.handle.net/20.500.11937/11908

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author	Law, M. Bishop, D. Lee, J. Brossard, M. Martin, N. Moses, Eric Song, F. Barrett, J. Kumar, R. Easton, D. Pharoah, P. Swerdlow, A. Kypreou, K. Taylor, J. Harland, M. Randerson-Moor, J. Akslen, L. Andresen, P. Avril, M. Azizi, E. Scarrà, G. Brown, K. Debniak, T. Duffy, D. Elder, D. Fang, S. Friedman, E. Galan, P. Ghiorzo, P. Gillanders, E. Goldstein, A. Gruis, N. Hansson, J. Helsing, P. Hocevar, M. Höiom, V. Ingvar, C. Kanetsky, P. Chen, W. Landi, M. Lang, J. Lathrop, G. Lubinski, J. MacKie, R. Mann, G. Molven, A. Montgomery, G. Novakovic, S. Olsson, H. Puig, S. Puig-Butille, J. Qureshi, A. Radford-Smith, G. Van Der Stoep, N. Van Doorn, R. Whiteman, D. Craig, J. Schadendorf, D. Simms, L. Burdon, K. Nyholt, D. Pooley, K. Orr, N. Stratigos, A. Cust, A. Ward, S. Hayward, N. Han, J. Schulze, H. Dunning, A. Bishop, J. Demenais, F. Amos, C. MacGregor, S. Iles, M.
author_facet	Law, M. Bishop, D. Lee, J. Brossard, M. Martin, N. Moses, Eric Song, F. Barrett, J. Kumar, R. Easton, D. Pharoah, P. Swerdlow, A. Kypreou, K. Taylor, J. Harland, M. Randerson-Moor, J. Akslen, L. Andresen, P. Avril, M. Azizi, E. Scarrà, G. Brown, K. Debniak, T. Duffy, D. Elder, D. Fang, S. Friedman, E. Galan, P. Ghiorzo, P. Gillanders, E. Goldstein, A. Gruis, N. Hansson, J. Helsing, P. Hocevar, M. Höiom, V. Ingvar, C. Kanetsky, P. Chen, W. Landi, M. Lang, J. Lathrop, G. Lubinski, J. MacKie, R. Mann, G. Molven, A. Montgomery, G. Novakovic, S. Olsson, H. Puig, S. Puig-Butille, J. Qureshi, A. Radford-Smith, G. Van Der Stoep, N. Van Doorn, R. Whiteman, D. Craig, J. Schadendorf, D. Simms, L. Burdon, K. Nyholt, D. Pooley, K. Orr, N. Stratigos, A. Cust, A. Ward, S. Hayward, N. Han, J. Schulze, H. Dunning, A. Bishop, J. Demenais, F. Amos, C. MacGregor, S. Iles, M.
author_sort	Law, M.
building	Curtin Institutional Repository
collection	Online Access
description	Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10−8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.
first_indexed	2025-11-14T06:56:58Z
format	Journal Article
id	curtin-20.500.11937-11908
institution	Curtin University Malaysia
institution_category	Local University
last_indexed	2025-11-14T06:56:58Z
publishDate	2015
recordtype	eprints
repository_type	Digital Repository
spelling	curtin-20.500.11937-119082018-03-29T09:05:56Z Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma Law, M. Bishop, D. Lee, J. Brossard, M. Martin, N. Moses, Eric Song, F. Barrett, J. Kumar, R. Easton, D. Pharoah, P. Swerdlow, A. Kypreou, K. Taylor, J. Harland, M. Randerson-Moor, J. Akslen, L. Andresen, P. Avril, M. Azizi, E. Scarrà, G. Brown, K. Debniak, T. Duffy, D. Elder, D. Fang, S. Friedman, E. Galan, P. Ghiorzo, P. Gillanders, E. Goldstein, A. Gruis, N. Hansson, J. Helsing, P. Hocevar, M. Höiom, V. Ingvar, C. Kanetsky, P. Chen, W. Landi, M. Lang, J. Lathrop, G. Lubinski, J. MacKie, R. Mann, G. Molven, A. Montgomery, G. Novakovic, S. Olsson, H. Puig, S. Puig-Butille, J. Qureshi, A. Radford-Smith, G. Van Der Stoep, N. Van Doorn, R. Whiteman, D. Craig, J. Schadendorf, D. Simms, L. Burdon, K. Nyholt, D. Pooley, K. Orr, N. Stratigos, A. Cust, A. Ward, S. Hayward, N. Han, J. Schulze, H. Dunning, A. Bishop, J. Demenais, F. Amos, C. MacGregor, S. Iles, M. Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10−8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology. 2015 Journal Article http://hdl.handle.net/20.500.11937/11908 10.1038/ng.3373 restricted
spellingShingle	Law, M. Bishop, D. Lee, J. Brossard, M. Martin, N. Moses, Eric Song, F. Barrett, J. Kumar, R. Easton, D. Pharoah, P. Swerdlow, A. Kypreou, K. Taylor, J. Harland, M. Randerson-Moor, J. Akslen, L. Andresen, P. Avril, M. Azizi, E. Scarrà, G. Brown, K. Debniak, T. Duffy, D. Elder, D. Fang, S. Friedman, E. Galan, P. Ghiorzo, P. Gillanders, E. Goldstein, A. Gruis, N. Hansson, J. Helsing, P. Hocevar, M. Höiom, V. Ingvar, C. Kanetsky, P. Chen, W. Landi, M. Lang, J. Lathrop, G. Lubinski, J. MacKie, R. Mann, G. Molven, A. Montgomery, G. Novakovic, S. Olsson, H. Puig, S. Puig-Butille, J. Qureshi, A. Radford-Smith, G. Van Der Stoep, N. Van Doorn, R. Whiteman, D. Craig, J. Schadendorf, D. Simms, L. Burdon, K. Nyholt, D. Pooley, K. Orr, N. Stratigos, A. Cust, A. Ward, S. Hayward, N. Han, J. Schulze, H. Dunning, A. Bishop, J. Demenais, F. Amos, C. MacGregor, S. Iles, M. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
title	Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
title_full	Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
title_fullStr	Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
title_full_unstemmed	Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
title_short	Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
title_sort	genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
url	http://hdl.handle.net/20.500.11937/11908

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

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