Brain Changes in Iron Loading Disorders
Abnormal iron accumulation within the brain is associated with various neurodegenerative diseases; however, there is debate about whether milder disorders of systemic iron loading, such as haemochromatosis, affect the brain. Arguments on both sides of the debate are often based on some common assump...
| Main Authors: | , , , , , , , , |
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| Format: | Book Chapter |
| Published: |
Springer-Verlag
2012
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/11473 |
| _version_ | 1848747815366295552 |
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| author | Milward, E. Acikyol, B. Bassett, B. Williams, E. Graham, Ross Delima, R. Trinder, D. Olynyk, John Johnstone, D. |
| author2 | Wolfgang Linert |
| author_facet | Wolfgang Linert Milward, E. Acikyol, B. Bassett, B. Williams, E. Graham, Ross Delima, R. Trinder, D. Olynyk, John Johnstone, D. |
| author_sort | Milward, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Abnormal iron accumulation within the brain is associated with various neurodegenerative diseases; however, there is debate about whether milder disorders of systemic iron loading, such as haemochromatosis, affect the brain. Arguments on both sides of the debate are often based on some common assumptions that have not been rigorously tested by appropriate experimentation. Recent research from our lab has applied high-throughput molecular techniques such as microarray to models of dietary and genetic iron loading to identify subtle but important effects on molecular systems in the brain that may go undetected by other methods commonly used in the field. In this chapter, we review the existing research in animal models and human patients and discuss the strengths and limitations of the different approaches commonly used. Using our findings as an example, we argue that transcriptomic methods can provide unique insights into how systemic iron loading can affect the brain and suggest some basic guidelines for extracting the most robust and reliable information from microarray studies. |
| first_indexed | 2025-11-14T06:55:08Z |
| format | Book Chapter |
| id | curtin-20.500.11937-11473 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:55:08Z |
| publishDate | 2012 |
| publisher | Springer-Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-114732023-02-02T07:57:37Z Brain Changes in Iron Loading Disorders Milward, E. Acikyol, B. Bassett, B. Williams, E. Graham, Ross Delima, R. Trinder, D. Olynyk, John Johnstone, D. Wolfgang Linert Henryk Kozlowski Microarray Mouse model Iron overload Brain HFE Abnormal iron accumulation within the brain is associated with various neurodegenerative diseases; however, there is debate about whether milder disorders of systemic iron loading, such as haemochromatosis, affect the brain. Arguments on both sides of the debate are often based on some common assumptions that have not been rigorously tested by appropriate experimentation. Recent research from our lab has applied high-throughput molecular techniques such as microarray to models of dietary and genetic iron loading to identify subtle but important effects on molecular systems in the brain that may go undetected by other methods commonly used in the field. In this chapter, we review the existing research in animal models and human patients and discuss the strengths and limitations of the different approaches commonly used. Using our findings as an example, we argue that transcriptomic methods can provide unique insights into how systemic iron loading can affect the brain and suggest some basic guidelines for extracting the most robust and reliable information from microarray studies. 2012 Book Chapter http://hdl.handle.net/20.500.11937/11473 Springer-Verlag restricted |
| spellingShingle | Microarray Mouse model Iron overload Brain HFE Milward, E. Acikyol, B. Bassett, B. Williams, E. Graham, Ross Delima, R. Trinder, D. Olynyk, John Johnstone, D. Brain Changes in Iron Loading Disorders |
| title | Brain Changes in Iron Loading Disorders |
| title_full | Brain Changes in Iron Loading Disorders |
| title_fullStr | Brain Changes in Iron Loading Disorders |
| title_full_unstemmed | Brain Changes in Iron Loading Disorders |
| title_short | Brain Changes in Iron Loading Disorders |
| title_sort | brain changes in iron loading disorders |
| topic | Microarray Mouse model Iron overload Brain HFE |
| url | http://hdl.handle.net/20.500.11937/11473 |