Pharmacokinetics and allometric scaling of antimalarial drugs
Allometric scaling was found as a plausible technique for dose determination in children. Permeability and P-glycoprotein efflux transport of antimalarials were determined using in-vitro Caco-2 cells. Mefloquine showed P-glycoprotein inhibition. Amodiaquine, artesunate and artemisone were not P-glyc...
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| Format: | Thesis |
| Language: | English |
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Curtin University
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/1139 |
| _version_ | 1848743582631985152 |
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| author | Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga |
| author_facet | Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga |
| author_sort | Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Allometric scaling was found as a plausible technique for dose determination in children. Permeability and P-glycoprotein efflux transport of antimalarials were determined using in-vitro Caco-2 cells. Mefloquine showed P-glycoprotein inhibition. Amodiaquine, artesunate and artemisone were not P-glycoprotein substrates or inhibitors. Methylene-blue showed some P-glycoprotein mediated efflux. Permeability was high for amodiaquine and artemisone, medium for mefloquine and artesunate and low for methylene-blue. P-glycoprotein was up-regulated when exposed to dihydroartemisinin/artemisone in combinations with amodiaquine/mefloquine. |
| first_indexed | 2025-11-14T05:47:52Z |
| format | Thesis |
| id | curtin-20.500.11937-1139 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:47:52Z |
| publishDate | 2015 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-11392017-02-20T06:39:39Z Pharmacokinetics and allometric scaling of antimalarial drugs Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga Allometric scaling was found as a plausible technique for dose determination in children. Permeability and P-glycoprotein efflux transport of antimalarials were determined using in-vitro Caco-2 cells. Mefloquine showed P-glycoprotein inhibition. Amodiaquine, artesunate and artemisone were not P-glycoprotein substrates or inhibitors. Methylene-blue showed some P-glycoprotein mediated efflux. Permeability was high for amodiaquine and artemisone, medium for mefloquine and artesunate and low for methylene-blue. P-glycoprotein was up-regulated when exposed to dihydroartemisinin/artemisone in combinations with amodiaquine/mefloquine. 2015 Thesis http://hdl.handle.net/20.500.11937/1139 en Curtin University fulltext |
| spellingShingle | Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga Pharmacokinetics and allometric scaling of antimalarial drugs |
| title | Pharmacokinetics and allometric scaling of antimalarial drugs |
| title_full | Pharmacokinetics and allometric scaling of antimalarial drugs |
| title_fullStr | Pharmacokinetics and allometric scaling of antimalarial drugs |
| title_full_unstemmed | Pharmacokinetics and allometric scaling of antimalarial drugs |
| title_short | Pharmacokinetics and allometric scaling of antimalarial drugs |
| title_sort | pharmacokinetics and allometric scaling of antimalarial drugs |
| url | http://hdl.handle.net/20.500.11937/1139 |