Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging
For thirty years, cyclotron-produced radioisotopes have attracted considerable interest in biomedicine. This thesis describes novel contributions to the production and purification of the positron-emission-tomography (PET) radioisotope copper-61, and its complexation to several bifunctional chelator...
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| Format: | Thesis |
| Language: | English |
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Curtin University
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/1132 |
| _version_ | 1848743580389081088 |
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| author | Asad, Ali Haidar Kasim |
| author_facet | Asad, Ali Haidar Kasim |
| author_sort | Asad, Ali Haidar Kasim |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | For thirty years, cyclotron-produced radioisotopes have attracted considerable interest in biomedicine. This thesis describes novel contributions to the production and purification of the positron-emission-tomography (PET) radioisotope copper-61, and its complexation to several bifunctional chelators. Using these technologies we determined the biodistributions of silica nanospheres (Si-NS) in a small-animal model. Si-NS are a promising nanoplatform for delivering diagnostic and therapeutic targeting agents at tumour-cellular level. This research has demonstrated significant potential for PET-radiometal radiophannaceuticals in theranostics. |
| first_indexed | 2025-11-14T05:47:50Z |
| format | Thesis |
| id | curtin-20.500.11937-1132 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:47:50Z |
| publishDate | 2016 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-11322017-02-20T06:39:51Z Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging Asad, Ali Haidar Kasim For thirty years, cyclotron-produced radioisotopes have attracted considerable interest in biomedicine. This thesis describes novel contributions to the production and purification of the positron-emission-tomography (PET) radioisotope copper-61, and its complexation to several bifunctional chelators. Using these technologies we determined the biodistributions of silica nanospheres (Si-NS) in a small-animal model. Si-NS are a promising nanoplatform for delivering diagnostic and therapeutic targeting agents at tumour-cellular level. This research has demonstrated significant potential for PET-radiometal radiophannaceuticals in theranostics. 2016 Thesis http://hdl.handle.net/20.500.11937/1132 en Curtin University fulltext |
| spellingShingle | Asad, Ali Haidar Kasim Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging |
| title | Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging |
| title_full | Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging |
| title_fullStr | Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging |
| title_full_unstemmed | Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging |
| title_short | Novel enhancements of cyclotron based production, purification & applications of the PET radionuclide copper-61: Complexation to nanospheres for biomedical imaging |
| title_sort | novel enhancements of cyclotron based production, purification & applications of the pet radionuclide copper-61: complexation to nanospheres for biomedical imaging |
| url | http://hdl.handle.net/20.500.11937/1132 |