Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors
Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the medium of Ras-tran...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Portland Press
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/11188 |
| _version_ | 1848747738676592640 |
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| author | Ruban, E. Ferro, R. Arifin, S. Falasca, Marco |
| author_facet | Ruban, E. Ferro, R. Arifin, S. Falasca, Marco |
| author_sort | Ruban, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the medium of Ras-transformed fibroblasts and can function as an autocrine modulator of cell growth. Different research groups have established that LPI is the specific and functional ligand for G-protein-coupled receptor 55 (GPR55) and that this GPR55–LPI axis is able to activate signalling cascades that are relevant for different cell functions. Work in our laboratory has recently unravelled an autocrine loop, by which LPI synthesized by cytosolic phospholipase A2 (cPLA2) is pumped out of the cell by ATP-binding cassette (ABC) transporter C1 (ABCC1)/multidrug resistance protein 1 (MRP1), initiating a signalling cascade downstream of GPR55. Our current work suggests that blockade of this pathway may represent a novel strategy to inhibit cancer cell proliferation. |
| first_indexed | 2025-11-14T06:53:55Z |
| format | Journal Article |
| id | curtin-20.500.11937-11188 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:53:55Z |
| publishDate | 2014 |
| publisher | Portland Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-111882017-09-13T14:53:52Z Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors Ruban, E. Ferro, R. Arifin, S. Falasca, Marco Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the medium of Ras-transformed fibroblasts and can function as an autocrine modulator of cell growth. Different research groups have established that LPI is the specific and functional ligand for G-protein-coupled receptor 55 (GPR55) and that this GPR55–LPI axis is able to activate signalling cascades that are relevant for different cell functions. Work in our laboratory has recently unravelled an autocrine loop, by which LPI synthesized by cytosolic phospholipase A2 (cPLA2) is pumped out of the cell by ATP-binding cassette (ABC) transporter C1 (ABCC1)/multidrug resistance protein 1 (MRP1), initiating a signalling cascade downstream of GPR55. Our current work suggests that blockade of this pathway may represent a novel strategy to inhibit cancer cell proliferation. 2014 Journal Article http://hdl.handle.net/20.500.11937/11188 10.1042/BST20140151 Portland Press restricted |
| spellingShingle | Ruban, E. Ferro, R. Arifin, S. Falasca, Marco Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors |
| title | Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors |
| title_full | Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors |
| title_fullStr | Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors |
| title_full_unstemmed | Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors |
| title_short | Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors |
| title_sort | lysophosphatidylinositol: a novel link between abc transporters and g-protein-coupled receptors |
| url | http://hdl.handle.net/20.500.11937/11188 |