P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism
OBJECTIVE: The aim of this study was to determine whether the presence of Helicobacter pylori (H. pylori) infection and multidrug resistance protein 1 (MDR1) C3435T polymorphism had an influence on P-glycoprotein (P-gp) expression in the upper gastrointestinal tract. METHODS: A total of 76 patients...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Wiley-Blackwell Publishing Asia
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/11169 |
| _version_ | 1848747733670690816 |
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| author | Omar, Marhanis Crowe, Andrew Parsons, Richard Ee, H. Tay, C. Hughes, Jeffery |
| author_facet | Omar, Marhanis Crowe, Andrew Parsons, Richard Ee, H. Tay, C. Hughes, Jeffery |
| author_sort | Omar, Marhanis |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | OBJECTIVE: The aim of this study was to determine whether the presence of Helicobacter pylori (H. pylori) infection and multidrug resistance protein 1 (MDR1) C3435T polymorphism had an influence on P-glycoprotein (P-gp) expression in the upper gastrointestinal tract. METHODS: A total of 76 patients who underwent upper gastroendoscopy at Sir Charles Gairdner Hospital in Western Australia from October 2010 to July 2011 were enrolled in the study. Antral and duodenal biopsies were collected for P-gp examination. Blood samples were taken and analyzed for MDR1 C3435T polymorphism. H. pylori infection status was confirmed by culture and polymerase chain reaction. RESULTS: A significant difference was found in P-gp expression between H. pylori-positive and H. pylori-negative patients (P = 0.028). For the MDR1 C3435T polymorphism, the TT genotype had a significantly lower P-gp expression compared with the CC genotype in antral specimens (P = 0.041). The homozygous TT genotype with H. pylori infection was also significantly different in P-gp expression compared with H. pylori-negative patients (P = 0.029). CONCLUSIONS: P-gp expression in the upper gastrointestinal tract is associated with H. pylori infection, and the TT genotype appeared to be associated with lower P-gp expression than the CC genotype in the stomach. |
| first_indexed | 2025-11-14T06:53:51Z |
| format | Journal Article |
| id | curtin-20.500.11937-11169 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:53:51Z |
| publishDate | 2012 |
| publisher | Wiley-Blackwell Publishing Asia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-111692017-09-13T15:54:08Z P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism Omar, Marhanis Crowe, Andrew Parsons, Richard Ee, H. Tay, C. Hughes, Jeffery single base polymorphism Helicobacter pylori P-glycoprotein peptic ulcer disease multidrug resistance OBJECTIVE: The aim of this study was to determine whether the presence of Helicobacter pylori (H. pylori) infection and multidrug resistance protein 1 (MDR1) C3435T polymorphism had an influence on P-glycoprotein (P-gp) expression in the upper gastrointestinal tract. METHODS: A total of 76 patients who underwent upper gastroendoscopy at Sir Charles Gairdner Hospital in Western Australia from October 2010 to July 2011 were enrolled in the study. Antral and duodenal biopsies were collected for P-gp examination. Blood samples were taken and analyzed for MDR1 C3435T polymorphism. H. pylori infection status was confirmed by culture and polymerase chain reaction. RESULTS: A significant difference was found in P-gp expression between H. pylori-positive and H. pylori-negative patients (P = 0.028). For the MDR1 C3435T polymorphism, the TT genotype had a significantly lower P-gp expression compared with the CC genotype in antral specimens (P = 0.041). The homozygous TT genotype with H. pylori infection was also significantly different in P-gp expression compared with H. pylori-negative patients (P = 0.029). CONCLUSIONS: P-gp expression in the upper gastrointestinal tract is associated with H. pylori infection, and the TT genotype appeared to be associated with lower P-gp expression than the CC genotype in the stomach. 2012 Journal Article http://hdl.handle.net/20.500.11937/11169 10.1111/j.1751-2980.2012.00606.x Wiley-Blackwell Publishing Asia restricted |
| spellingShingle | single base polymorphism Helicobacter pylori P-glycoprotein peptic ulcer disease multidrug resistance Omar, Marhanis Crowe, Andrew Parsons, Richard Ee, H. Tay, C. Hughes, Jeffery P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism |
| title | P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism |
| title_full | P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism |
| title_fullStr | P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism |
| title_full_unstemmed | P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism |
| title_short | P-glycoprotein expression in Helicobacter pylori-positive patients: The influence of MDR1 C3435T polymorphism |
| title_sort | p-glycoprotein expression in helicobacter pylori-positive patients: the influence of mdr1 c3435t polymorphism |
| topic | single base polymorphism Helicobacter pylori P-glycoprotein peptic ulcer disease multidrug resistance |
| url | http://hdl.handle.net/20.500.11937/11169 |