Iron and Hepatic Carcinogenesis
Iron is an essential co-factor for life; however, a physiologically optimal balance is critical. Too much or too little iron can have detrimental effects on human health. In this article, we explore the relationships between iron and hepatocellular carcinoma (HCC). Iron can act as a modulating co-fa...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Begell House
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/11138 |
| _version_ | 1848747724958072832 |
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| author | Tirnitz-Parker, Janina Glanfield, A. Olynyk, John Ramm, G. |
| author_facet | Tirnitz-Parker, Janina Glanfield, A. Olynyk, John Ramm, G. |
| author_sort | Tirnitz-Parker, Janina |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Iron is an essential co-factor for life; however, a physiologically optimal balance is critical. Too much or too little iron can have detrimental effects on human health. In this article, we explore the relationships between iron and hepatocellular carcinoma (HCC). Iron can act as a modulating co-factor in a range of chronic liver diseases and can accelerate the development of liver injury, fibrosis, cirrhosis, and ultimately HCC. Iron can, however, also act as a sole factor in the causation of liver cirrhosis and HCC in individuals with hereditary hemochromatosis (HH). We overview the regulation of normal iron metabolism and the role of iron in wound healing and associated cell types as well as in pathophysiologies that predispose to HCC. We review how these injury pro- cesses are inextricably linked, providing a mechanistic basis for understanding how iron and hepatic injury potentially result in HCC. |
| first_indexed | 2025-11-14T06:53:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-11138 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:53:42Z |
| publishDate | 2013 |
| publisher | Begell House |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-111382017-09-13T14:53:18Z Iron and Hepatic Carcinogenesis Tirnitz-Parker, Janina Glanfield, A. Olynyk, John Ramm, G. liver progenitor cell reactive oxygen species hepatic fibrosis liver hepatocellular carcinoma iron cirrhosis Iron is an essential co-factor for life; however, a physiologically optimal balance is critical. Too much or too little iron can have detrimental effects on human health. In this article, we explore the relationships between iron and hepatocellular carcinoma (HCC). Iron can act as a modulating co-factor in a range of chronic liver diseases and can accelerate the development of liver injury, fibrosis, cirrhosis, and ultimately HCC. Iron can, however, also act as a sole factor in the causation of liver cirrhosis and HCC in individuals with hereditary hemochromatosis (HH). We overview the regulation of normal iron metabolism and the role of iron in wound healing and associated cell types as well as in pathophysiologies that predispose to HCC. We review how these injury pro- cesses are inextricably linked, providing a mechanistic basis for understanding how iron and hepatic injury potentially result in HCC. 2013 Journal Article http://hdl.handle.net/20.500.11937/11138 10.1615/CritRevOncog.2013007759 Begell House restricted |
| spellingShingle | liver progenitor cell reactive oxygen species hepatic fibrosis liver hepatocellular carcinoma iron cirrhosis Tirnitz-Parker, Janina Glanfield, A. Olynyk, John Ramm, G. Iron and Hepatic Carcinogenesis |
| title | Iron and Hepatic Carcinogenesis |
| title_full | Iron and Hepatic Carcinogenesis |
| title_fullStr | Iron and Hepatic Carcinogenesis |
| title_full_unstemmed | Iron and Hepatic Carcinogenesis |
| title_short | Iron and Hepatic Carcinogenesis |
| title_sort | iron and hepatic carcinogenesis |
| topic | liver progenitor cell reactive oxygen species hepatic fibrosis liver hepatocellular carcinoma iron cirrhosis |
| url | http://hdl.handle.net/20.500.11937/11138 |