Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and ß-Cell Dysfunction
The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation are key physiological and pathological events linking obesity, insulin resistance, and the progression of type 2 DM (T2DM)....
| Main Authors: | Keane, Kevin, Cruzat, Vinicius, Carlessi, Rodrigo, Ivo, P., De Bittencourt, P., Newsholme, Philip |
|---|---|
| Format: | Journal Article |
| Published: |
Hindawi Publishing Corporation
2015
|
| Online Access: | http://hdl.handle.net/20.500.11937/11058 |
Similar Items
Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic ß-cell bioenergetic parameters and metabolism in BRIN-BD11 cells
by: Rowlands, Jordan, et al.
Published: (2018)
by: Rowlands, Jordan, et al.
Published: (2018)
Molecular mechanisms of ROS production and oxidative stress in diabetes
by: Newsholme, Philip, et al.
Published: (2016)
by: Newsholme, Philip, et al.
Published: (2016)
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease
by: Verdile, Giuseppe, et al.
Published: (2015)
by: Verdile, Giuseppe, et al.
Published: (2015)
The Impact of Inflammation on Pancreatic ß-Cell Metabolism, Function and Failure in T1DM and T2DM: Commonalities and Differences
by: Newsholme, Philip, et al.
Published: (2013)
by: Newsholme, Philip, et al.
Published: (2013)
Nutrient regulation of insulin secretion and action
by: Newsholme, Philip, et al.
Published: (2014)
by: Newsholme, Philip, et al.
Published: (2014)
The bioenergetics of inflammation: insights into obesity and type 2 diabetes
by: Keane, Kevin, et al.
Published: (2017)
by: Keane, Kevin, et al.
Published: (2017)
Nutrient regulation of ß-cell function: what do islet cell/animal studies tell us?
by: Carlessi, Rodrigo, et al.
Published: (2017)
by: Carlessi, Rodrigo, et al.
Published: (2017)
Alanyl-glutamine improves pancreatic ß-cell function following ex vivo inflammatory challenge
by: Cruzat, Vinicius, et al.
Published: (2015)
by: Cruzat, Vinicius, et al.
Published: (2015)
Metabolic Regulation of Insulin Secretion
by: Keane, Kevin, et al.
Published: (2014)
by: Keane, Kevin, et al.
Published: (2014)
Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic ß-cell dysfunction and death in vitro.
by: Krause, M., et al.
Published: (2013)
by: Krause, M., et al.
Published: (2013)
Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic ß-cells
by: Keane, D., et al.
Published: (2008)
by: Keane, D., et al.
Published: (2008)
Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets
by: Chen, Y., et al.
Published: (2016)
by: Chen, Y., et al.
Published: (2016)
β-cell metabolism, insulin production and secretion: Metabolic failure resulting in diabetes
by: Chen, Y., et al.
Published: (2016)
by: Chen, Y., et al.
Published: (2016)
Method Protocols for Metabolic and Functional Analysis of the BRIN-BD11 ß-Cell Line: A Preclinical Model for Type 2 Diabetes
by: Rowlands, J., et al.
Published: (2019)
by: Rowlands, J., et al.
Published: (2019)
The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease
by: Newsholme, Philip, et al.
Published: (2014)
by: Newsholme, Philip, et al.
Published: (2014)
Nutrient regulation of insulin secretion and ß-cell functional integrity
by: Newsholme, Philip, et al.
Published: (2010)
by: Newsholme, Philip, et al.
Published: (2010)
Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia
by: Cruzat, Vinicius, et al.
Published: (2014)
by: Cruzat, Vinicius, et al.
Published: (2014)
GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation
by: Carlessi, Rodrigo, et al.
Published: (2017)
by: Carlessi, Rodrigo, et al.
Published: (2017)
Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic ß-cell line and mouse islets
by: Da Silva Krause, M., et al.
Published: (2012)
by: Da Silva Krause, M., et al.
Published: (2012)
(Dys)Regulation of Insulin Secretion by Macronutrients
by: Newsholme, Philip, et al.
Published: (2015)
by: Newsholme, Philip, et al.
Published: (2015)
Glutamine deprivation induces metabolic adaptations associated with beta cell dysfunction and exacerbate lipotoxicity
by: Carlessi, Rodrigo, et al.
Published: (2018)
by: Carlessi, Rodrigo, et al.
Published: (2018)
Glutamine: Metabolism and immune function, supplementation and clinical translation
by: Cruzat, Vinicius, et al.
Published: (2018)
by: Cruzat, Vinicius, et al.
Published: (2018)
The impact of cryopreservation on human peripheral blood leucocyte bioenergetics
by: Keane, Kevin, et al.
Published: (2015)
by: Keane, Kevin, et al.
Published: (2015)
Glutamine and the immune system
by: Cruzat, Vinicius, et al.
Published: (2017)
by: Cruzat, Vinicius, et al.
Published: (2017)
An introduction to glutamine metabolism
by: Cruzat, Vinicius, et al.
Published: (2017)
by: Cruzat, Vinicius, et al.
Published: (2017)
Lupin seed hydrolysate promotes G-protein-coupled receptor, intracellular Ca2+ and enhanced glycolytic metabolism-mediated insulin secretion from BRIN-BD11 pancreatic beta cells
by: Tapadia, M., et al.
Published: (2018)
by: Tapadia, M., et al.
Published: (2018)
Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome
by: Keane, Kevin, et al.
Published: (2016)
by: Keane, Kevin, et al.
Published: (2016)
Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 ß-cell insulin secretion and signal transduction
by: Kiely, A., et al.
Published: (2009)
by: Kiely, A., et al.
Published: (2009)
The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes
by: Krause, M., et al.
Published: (2015)
by: Krause, M., et al.
Published: (2015)
Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
by: Kwaifa, Ibrahim Kalle, et al.
Published: (2020)
by: Kwaifa, Ibrahim Kalle, et al.
Published: (2020)
The chaperone balance hypothesis: The importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management
by: Krause, M., et al.
Published: (2015)
by: Krause, M., et al.
Published: (2015)
Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic ß-cell line
by: Mooranian, A., et al.
Published: (2015)
by: Mooranian, A., et al.
Published: (2015)
The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-ß, Amylin, and Tau Proteins
by: Bharadwaj, Prashant, et al.
Published: (2017)
by: Bharadwaj, Prashant, et al.
Published: (2017)
Amino acid supplementation and impact on immune function in the context of exercise
by: Cruzat, Vinicius, et al.
Published: (2014)
by: Cruzat, Vinicius, et al.
Published: (2014)
Blood-brain barrier dysfunction precedes cognitive decline and neurodegeneration in diabetic insulin resistant mouse model: An implication for causal link
by: Takechi, Ryu, et al.
Published: (2017)
by: Takechi, Ryu, et al.
Published: (2017)
Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal ß-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism
by: Bender, K., et al.
Published: (2009)
by: Bender, K., et al.
Published: (2009)
Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic ß-cells
by: McClenaghan, N., et al.
Published: (2009)
by: McClenaghan, N., et al.
Published: (2009)
Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise
by: Cruzat, Vinicius, et al.
Published: (2010)
by: Cruzat, Vinicius, et al.
Published: (2010)
Synergy Between Adiposity, Insulin Resistance, Metabolic Risk Factors, and Inflammation in Adolescents
by: Huang, R., et al.
Published: (2009)
by: Huang, R., et al.
Published: (2009)
Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: Findings from a linked-data study
by: Chew, K., et al.
Published: (2010)
by: Chew, K., et al.
Published: (2010)
Similar Items
-
Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic ß-cell bioenergetic parameters and metabolism in BRIN-BD11 cells
by: Rowlands, Jordan, et al.
Published: (2018) -
Molecular mechanisms of ROS production and oxidative stress in diabetes
by: Newsholme, Philip, et al.
Published: (2016) -
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease
by: Verdile, Giuseppe, et al.
Published: (2015) -
The Impact of Inflammation on Pancreatic ß-Cell Metabolism, Function and Failure in T1DM and T2DM: Commonalities and Differences
by: Newsholme, Philip, et al.
Published: (2013) -
Nutrient regulation of insulin secretion and action
by: Newsholme, Philip, et al.
Published: (2014)