Process Intensification: Nano-Carrier Formation by a Continuous Dense Gas Process
Formation of nano-carriers such as vesicles and micelles using dense gas processing has been under extensive research for decades. Several dense gas processes have been developed to produce nano-carriers, most of them being batch processes. In the present study, a novel continuous dense gas, known a...
| Main Authors: | , , |
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| Format: | Journal Article |
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Elsevier BV
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/10959 |
| _version_ | 1848747676946923520 |
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| author | Beh, C. Mammucari, R. Foster, Neil |
| author_facet | Beh, C. Mammucari, R. Foster, Neil |
| author_sort | Beh, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Formation of nano-carriers such as vesicles and micelles using dense gas processing has been under extensive research for decades. Several dense gas processes have been developed to produce nano-carriers, most of them being batch processes. In the present study, a novel continuous dense gas, known as nano-carrier by a continuous dense gas (NADEG) process was developed as an evolution of a dense gas batch process known as the Depressurization of an Expanded Solution into Aqueous Media (DESAM) process. Transforming a batch process into a continuous process is a main aspect of process intensification. The NADEG process developed in this work enhances the production output of the batch process while producing nano-carriers free of harmful residual organic solvent. The NADEG process is a one-step process for the production of nano-carriers with lower size and higher encapsulation efficiency than the nano-carriers produced by other batch processes. Encapsulation efficiencies as high as 15% were achieved using liposomes to encapsulate a model hydrophilic compound (isoniazid) while encapsulation efficiencies of 10% were achieved in polymersomes for the same model compound. |
| first_indexed | 2025-11-14T06:52:56Z |
| format | Journal Article |
| id | curtin-20.500.11937-10959 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:52:56Z |
| publishDate | 2015 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-109592017-09-13T14:55:04Z Process Intensification: Nano-Carrier Formation by a Continuous Dense Gas Process Beh, C. Mammucari, R. Foster, Neil Formation of nano-carriers such as vesicles and micelles using dense gas processing has been under extensive research for decades. Several dense gas processes have been developed to produce nano-carriers, most of them being batch processes. In the present study, a novel continuous dense gas, known as nano-carrier by a continuous dense gas (NADEG) process was developed as an evolution of a dense gas batch process known as the Depressurization of an Expanded Solution into Aqueous Media (DESAM) process. Transforming a batch process into a continuous process is a main aspect of process intensification. The NADEG process developed in this work enhances the production output of the batch process while producing nano-carriers free of harmful residual organic solvent. The NADEG process is a one-step process for the production of nano-carriers with lower size and higher encapsulation efficiency than the nano-carriers produced by other batch processes. Encapsulation efficiencies as high as 15% were achieved using liposomes to encapsulate a model hydrophilic compound (isoniazid) while encapsulation efficiencies of 10% were achieved in polymersomes for the same model compound. 2015 Journal Article http://hdl.handle.net/20.500.11937/10959 10.1016/j.cej.2014.12.072 Elsevier BV restricted |
| spellingShingle | Beh, C. Mammucari, R. Foster, Neil Process Intensification: Nano-Carrier Formation by a Continuous Dense Gas Process |
| title | Process Intensification: Nano-Carrier Formation by a Continuous Dense Gas Process |
| title_full | Process Intensification: Nano-Carrier Formation by a Continuous Dense Gas Process |
| title_fullStr | Process Intensification: Nano-Carrier Formation by a Continuous Dense Gas Process |
| title_full_unstemmed | Process Intensification: Nano-Carrier Formation by a Continuous Dense Gas Process |
| title_short | Process Intensification: Nano-Carrier Formation by a Continuous Dense Gas Process |
| title_sort | process intensification: nano-carrier formation by a continuous dense gas process |
| url | http://hdl.handle.net/20.500.11937/10959 |