The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease
Myeloid-derived suppressor cells (MDSC) have been implicated in the regulation of chronic inflammation. Chronic obstructive pulmonary disease (COPD) involves persistent inflammation, but the role of MDSC has not been explored. Here, proportions of MDSC (CD14-HLA-DR-CD33+CD11b+ cells) were quantified...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Elsevier Inc.
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/10768 |
| _version_ | 1848747623548190720 |
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| author | Tan, D. Fernandez, S. Price, Patricia Moodley, Y. |
| author_facet | Tan, D. Fernandez, S. Price, Patricia Moodley, Y. |
| author_sort | Tan, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Myeloid-derived suppressor cells (MDSC) have been implicated in the regulation of chronic inflammation. Chronic obstructive pulmonary disease (COPD) involves persistent inflammation, but the role of MDSC has not been explored. Here, proportions of MDSC (CD14-HLA-DR-CD33+CD11b+ cells) were quantified in peripheral blood mononuclear cells (PBMC) isolated from patients with ‘stable’ COPD (n = 12), smokers with no evidence of COPD (n = 11) and healthy non-smokers (n = 11). The proportions of MDSC were similar in all groups. MDSC function was assessed by comparing T-cell and cytokine responses of whole and MDSC-depleted PBMC stimulated with Staphylococcus enterotoxin-B (SEB). Depletion of MDSC did not enhance CD4+ or CD8+ T-cell activation and proliferation, or alter IFN? and IL-17 production in response to SEB. However production of TGFß decreased after depletion of MDSC, so MDSC may be a source of this cytokine. In conclusion, COPD was not associated with perturbations in the proportion or function of MDSC in peripheral blood. |
| first_indexed | 2025-11-14T06:52:06Z |
| format | Journal Article |
| id | curtin-20.500.11937-10768 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:52:06Z |
| publishDate | 2014 |
| publisher | Elsevier Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-107682017-09-13T14:53:18Z The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease Tan, D. Fernandez, S. Price, Patricia Moodley, Y. Myeloid-derived suppressor cells (MDSC) have been implicated in the regulation of chronic inflammation. Chronic obstructive pulmonary disease (COPD) involves persistent inflammation, but the role of MDSC has not been explored. Here, proportions of MDSC (CD14-HLA-DR-CD33+CD11b+ cells) were quantified in peripheral blood mononuclear cells (PBMC) isolated from patients with ‘stable’ COPD (n = 12), smokers with no evidence of COPD (n = 11) and healthy non-smokers (n = 11). The proportions of MDSC were similar in all groups. MDSC function was assessed by comparing T-cell and cytokine responses of whole and MDSC-depleted PBMC stimulated with Staphylococcus enterotoxin-B (SEB). Depletion of MDSC did not enhance CD4+ or CD8+ T-cell activation and proliferation, or alter IFN? and IL-17 production in response to SEB. However production of TGFß decreased after depletion of MDSC, so MDSC may be a source of this cytokine. In conclusion, COPD was not associated with perturbations in the proportion or function of MDSC in peripheral blood. 2014 Journal Article http://hdl.handle.net/20.500.11937/10768 10.1016/j.humimm.2013.09.011 Elsevier Inc. restricted |
| spellingShingle | Tan, D. Fernandez, S. Price, Patricia Moodley, Y. The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease |
| title | The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease |
| title_full | The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease |
| title_fullStr | The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease |
| title_full_unstemmed | The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease |
| title_short | The proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease |
| title_sort | proportion and function of peripheral myeloid-derived suppressor cells do not correlate with systemic inflammation in chronic obstructive pulmonary disease |
| url | http://hdl.handle.net/20.500.11937/10768 |