STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study
Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 stud...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/10699 |
| _version_ | 1848747605073330176 |
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| author | Fenstad, M. Johnson, M. Løset, M. Mundal, S. Roten, L. Eide, I. Bjørge, L. Sande, R. Johansson, A. Dyer, T. Forsmo, S. Blangero, J. Moses, Eric Austgulen, R. |
| author_facet | Fenstad, M. Johnson, M. Løset, M. Mundal, S. Roten, L. Eide, I. Bjørge, L. Sande, R. Johansson, A. Dyer, T. Forsmo, S. Blangero, J. Moses, Eric Austgulen, R. |
| author_sort | Fenstad, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR. © The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. |
| first_indexed | 2025-11-14T06:51:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-10699 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:51:48Z |
| publishDate | 2010 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-106992017-09-13T14:56:20Z STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study Fenstad, M. Johnson, M. Løset, M. Mundal, S. Roten, L. Eide, I. Bjørge, L. Sande, R. Johansson, A. Dyer, T. Forsmo, S. Blangero, J. Moses, Eric Austgulen, R. Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR. © The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. 2010 Journal Article http://hdl.handle.net/20.500.11937/10699 10.1093/molehr/gaq064 unknown |
| spellingShingle | Fenstad, M. Johnson, M. Løset, M. Mundal, S. Roten, L. Eide, I. Bjørge, L. Sande, R. Johansson, A. Dyer, T. Forsmo, S. Blangero, J. Moses, Eric Austgulen, R. STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study |
| title | STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study |
| title_full | STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study |
| title_fullStr | STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study |
| title_full_unstemmed | STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study |
| title_short | STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study |
| title_sort | stox2 but not stox1 is differentially expressed in decidua from preeclamptic women: data from the second nord-trøndelag health study |
| url | http://hdl.handle.net/20.500.11937/10699 |