Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients
HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs)...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Springer
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/10666 |
| _version_ | 1848747596030410752 |
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| author | Goullee, H. Wadley, A. Cherry, C. Allcock, R. Black, M. Kamerman, P. Price, Patricia |
| author_facet | Goullee, H. Wadley, A. Cherry, C. Allcock, R. Black, M. Kamerman, P. Price, Patricia |
| author_sort | Goullee, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R, P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV+ black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p < 0.0001; R2 = 0.19) or haplotypes (model p < 0.0001; R2 = 0.18, n = 137 excluding patients carrying CAMKK2 haplotypes perfectly associated with SN). Overall, CAMKK2 exhibited the strongest associations with HIV-SN, with two SNPs and six haplotypes predicting SN status in black Southern Africans. This gene warrants further study. |
| first_indexed | 2025-11-14T06:51:39Z |
| format | Journal Article |
| id | curtin-20.500.11937-10666 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:51:39Z |
| publishDate | 2016 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-106662019-02-19T05:34:46Z Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients Goullee, H. Wadley, A. Cherry, C. Allcock, R. Black, M. Kamerman, P. Price, Patricia HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R, P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV+ black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p < 0.0001; R2 = 0.19) or haplotypes (model p < 0.0001; R2 = 0.18, n = 137 excluding patients carrying CAMKK2 haplotypes perfectly associated with SN). Overall, CAMKK2 exhibited the strongest associations with HIV-SN, with two SNPs and six haplotypes predicting SN status in black Southern Africans. This gene warrants further study. 2016 Journal Article http://hdl.handle.net/20.500.11937/10666 10.1007/s13365-015-0421-4 Springer fulltext |
| spellingShingle | Goullee, H. Wadley, A. Cherry, C. Allcock, R. Black, M. Kamerman, P. Price, Patricia Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients |
| title | Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients |
| title_full | Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients |
| title_fullStr | Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients |
| title_full_unstemmed | Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients |
| title_short | Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients |
| title_sort | polymorphisms in camkk2 may predict sensory neuropathy in african hiv patients |
| url | http://hdl.handle.net/20.500.11937/10666 |