Development of natural gum based glipizide mucoadhesive microsphere
The objective of this study was to develop glipizide microsphere with natural gums. Guar gum and xanthan gum were used separately in different ratios as natural polymers. The microspheres were prepared by orifice ionic gelation method and they were characterized by scanning electron microscopy and p...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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Medipoeia Publication
2014
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| Online Access: | http://www.japsonline.com/admin/php/uploads/1160_pdf.pdf http://hdl.handle.net/20.500.11937/10582 |
| _version_ | 1848747572880998400 |
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| author | Al Mamun, A. Bagchi, M. Amin, L. Sutradhar, K. Huda, Naz |
| author_facet | Al Mamun, A. Bagchi, M. Amin, L. Sutradhar, K. Huda, Naz |
| author_sort | Al Mamun, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The objective of this study was to develop glipizide microsphere with natural gums. Guar gum and xanthan gum were used separately in different ratios as natural polymers. The microspheres were prepared by orifice ionic gelation method and they were characterized by scanning electron microscopy and particle size analysis. Among six formulations, microspheres of four formulations (F1-F4) were discrete, spherical and free flowing. There was an inverse relationship found between the amount of gum and surface smoothness in case of guar gum-containing microspheres while a forward relationship was found between amount of gum and surface smoothness in case of the microspheres containing xanthan gum. The size of the particles increased with increasing amounts of gum. It can be concluded that guar gum and natural gum at a ratio of 1:0.25 and 1:0.5 can be ideal for formulating natural gum based glipizide mucoadhesive microsphere. |
| first_indexed | 2025-11-14T06:51:17Z |
| format | Journal Article |
| id | curtin-20.500.11937-10582 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:51:17Z |
| publishDate | 2014 |
| publisher | Medipoeia Publication |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-105822017-01-30T11:19:44Z Development of natural gum based glipizide mucoadhesive microsphere Al Mamun, A. Bagchi, M. Amin, L. Sutradhar, K. Huda, Naz Glipizide xanthan gum ionic gelation method guar gum mucoadhesive microsphere The objective of this study was to develop glipizide microsphere with natural gums. Guar gum and xanthan gum were used separately in different ratios as natural polymers. The microspheres were prepared by orifice ionic gelation method and they were characterized by scanning electron microscopy and particle size analysis. Among six formulations, microspheres of four formulations (F1-F4) were discrete, spherical and free flowing. There was an inverse relationship found between the amount of gum and surface smoothness in case of guar gum-containing microspheres while a forward relationship was found between amount of gum and surface smoothness in case of the microspheres containing xanthan gum. The size of the particles increased with increasing amounts of gum. It can be concluded that guar gum and natural gum at a ratio of 1:0.25 and 1:0.5 can be ideal for formulating natural gum based glipizide mucoadhesive microsphere. 2014 Journal Article http://hdl.handle.net/20.500.11937/10582 http://www.japsonline.com/admin/php/uploads/1160_pdf.pdf Medipoeia Publication fulltext |
| spellingShingle | Glipizide xanthan gum ionic gelation method guar gum mucoadhesive microsphere Al Mamun, A. Bagchi, M. Amin, L. Sutradhar, K. Huda, Naz Development of natural gum based glipizide mucoadhesive microsphere |
| title | Development of natural gum based glipizide mucoadhesive microsphere |
| title_full | Development of natural gum based glipizide mucoadhesive microsphere |
| title_fullStr | Development of natural gum based glipizide mucoadhesive microsphere |
| title_full_unstemmed | Development of natural gum based glipizide mucoadhesive microsphere |
| title_short | Development of natural gum based glipizide mucoadhesive microsphere |
| title_sort | development of natural gum based glipizide mucoadhesive microsphere |
| topic | Glipizide xanthan gum ionic gelation method guar gum mucoadhesive microsphere |
| url | http://www.japsonline.com/admin/php/uploads/1160_pdf.pdf http://hdl.handle.net/20.500.11937/10582 |