Molecular Modeling Study for Inhibition Mechanism of Human Chymase and Its Application in Inhibitor Design

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Molecular Modeling Study for Inhibition Mechanism of Human Chymase and Its Application in Inhibitor Design

Human chymase catalyzes the hydrolysis of peptide bonds. Three chymase inhibitors with very similar chemical structures but highly different inhibitory profiles towards the hydrolase function of chymase were selected with the aim of elucidating the origin of disparities in their biological activitie...

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Bibliographic Details
Main Authors:	Arooj, Mahreen, Kim, Songmi, Sakkiah, Sugunadevi, Ping Cao, Guang, Lee, Yuno, Woo Lee, Keun
Format:	Journal Article
Published:	Public Library of Science 2013
Online Access:	http://hdl.handle.net/20.500.11937/10504

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