Platelet Receptor Shedding
Receptor shedding is a mechanism for irreversible removal of transmembrane cell surf.1ce receptors by proteolysis of the receptor at a position near the extracellular surface of the plasma membrane. This process generates a soluble ectodomain fragment and a membrane-associated remnant fragment, and...
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| Format: | Book Chapter |
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Springer
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/10489 |
| _version_ | 1848747547522236416 |
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| author | Gardiner, E. Al-Tamimi, M. Robert, A. Berndt, Michael |
| author2 | Jonathan M Gibbins |
| author_facet | Jonathan M Gibbins Gardiner, E. Al-Tamimi, M. Robert, A. Berndt, Michael |
| author_sort | Gardiner, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Receptor shedding is a mechanism for irreversible removal of transmembrane cell surf.1ce receptors by proteolysis of the receptor at a position near the extracellular surface of the plasma membrane. This process generates a soluble ectodomain fragment and a membrane-associated remnant fragment, and is distinct from loss of receptor surface expression by internalization or microparticle release or secretion of alternatively spliced soluble forms of receptors lacking a transmembrane domain. There has been an increased focus on new methods for analyzing shedding of platelet glycoprotein (GP)Ib-IX-V and GPVI because these receptors are platelet specific and are critical for the initiation of platelet adhesion and activation in thrombus formation at arterial shear rates. Platelet receptor shedding provides a mechanism for downregulating surface expression resulting in loss of ligand binding, decreasing the surface density affecting receptor cross linking and signalling and generation of proteolytic fragments that may be functional and/ or provide platelet-specific biomarkers. |
| first_indexed | 2025-11-14T06:50:53Z |
| format | Book Chapter |
| id | curtin-20.500.11937-10489 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:50:53Z |
| publishDate | 2012 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-104892023-02-02T07:57:37Z Platelet Receptor Shedding Gardiner, E. Al-Tamimi, M. Robert, A. Berndt, Michael Jonathan M Gibbins Martyn P. Mahaut-Smith GPib-IX-V ADAMI 0 GPVI Receptors Platelets ADAMI7 Sheddases Receptor shedding is a mechanism for irreversible removal of transmembrane cell surf.1ce receptors by proteolysis of the receptor at a position near the extracellular surface of the plasma membrane. This process generates a soluble ectodomain fragment and a membrane-associated remnant fragment, and is distinct from loss of receptor surface expression by internalization or microparticle release or secretion of alternatively spliced soluble forms of receptors lacking a transmembrane domain. There has been an increased focus on new methods for analyzing shedding of platelet glycoprotein (GP)Ib-IX-V and GPVI because these receptors are platelet specific and are critical for the initiation of platelet adhesion and activation in thrombus formation at arterial shear rates. Platelet receptor shedding provides a mechanism for downregulating surface expression resulting in loss of ligand binding, decreasing the surface density affecting receptor cross linking and signalling and generation of proteolytic fragments that may be functional and/ or provide platelet-specific biomarkers. 2012 Book Chapter http://hdl.handle.net/20.500.11937/10489 10.1007/978-1-61779-307-3_22 Springer restricted |
| spellingShingle | GPib-IX-V ADAMI 0 GPVI Receptors Platelets ADAMI7 Sheddases Gardiner, E. Al-Tamimi, M. Robert, A. Berndt, Michael Platelet Receptor Shedding |
| title | Platelet Receptor Shedding |
| title_full | Platelet Receptor Shedding |
| title_fullStr | Platelet Receptor Shedding |
| title_full_unstemmed | Platelet Receptor Shedding |
| title_short | Platelet Receptor Shedding |
| title_sort | platelet receptor shedding |
| topic | GPib-IX-V ADAMI 0 GPVI Receptors Platelets ADAMI7 Sheddases |
| url | http://hdl.handle.net/20.500.11937/10489 |