Development of a Pharmacodynamic Model of Murine Malaria
The rational design of antimalarial therapies has historically been compromised by a paucity of pharmacodynamic data contributing to resistance through deployment of suboptimal doses. This thesis demonstrates a modified P. berghei murine malaria model for collecting detailed in vivo pharmacodynamic...
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| Format: | Thesis |
| Language: | English |
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Curtin University
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/1031 |
| _version_ | 1848743552005177344 |
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| author | Gibbons, Peter Luke |
| author_facet | Gibbons, Peter Luke |
| author_sort | Gibbons, Peter Luke |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The rational design of antimalarial therapies has historically been compromised by a paucity of pharmacodynamic data contributing to resistance through deployment of suboptimal doses. This thesis demonstrates a modified P. berghei murine malaria model for collecting detailed in vivo pharmacodynamic data and novel in silico mathematical model enabling optimisation of dosing and combination therapy. These models contribute to preclinical knowledge and provide the potential to assist in the development of methods to optimise clinical treatment. |
| first_indexed | 2025-11-14T05:47:23Z |
| format | Thesis |
| id | curtin-20.500.11937-1031 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:47:23Z |
| publishDate | 2015 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-10312017-02-20T06:42:17Z Development of a Pharmacodynamic Model of Murine Malaria Gibbons, Peter Luke The rational design of antimalarial therapies has historically been compromised by a paucity of pharmacodynamic data contributing to resistance through deployment of suboptimal doses. This thesis demonstrates a modified P. berghei murine malaria model for collecting detailed in vivo pharmacodynamic data and novel in silico mathematical model enabling optimisation of dosing and combination therapy. These models contribute to preclinical knowledge and provide the potential to assist in the development of methods to optimise clinical treatment. 2015 Thesis http://hdl.handle.net/20.500.11937/1031 en Curtin University fulltext |
| spellingShingle | Gibbons, Peter Luke Development of a Pharmacodynamic Model of Murine Malaria |
| title | Development of a Pharmacodynamic Model of Murine Malaria |
| title_full | Development of a Pharmacodynamic Model of Murine Malaria |
| title_fullStr | Development of a Pharmacodynamic Model of Murine Malaria |
| title_full_unstemmed | Development of a Pharmacodynamic Model of Murine Malaria |
| title_short | Development of a Pharmacodynamic Model of Murine Malaria |
| title_sort | development of a pharmacodynamic model of murine malaria |
| url | http://hdl.handle.net/20.500.11937/1031 |