CFD Approach for Non-Ideally Mixed Bioreactor Modeling
In this paper, we address the progress, challenges and prospect of modeling mixing in bioreactor by the utilization of Computational Fluid Dynamics (CFD). Efficient operation of bioreactor is essential in the biotechnological process, not only to ensure good yield but also to maintain consistent pro...
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| Format: | Conference Paper |
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CUTSE 2009
2009
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/10249 |
| _version_ | 1848746179972562944 |
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| author | Liew, Emily Kumar, Perumal Samyudia, Yudi |
| author2 | Agus et al. |
| author_facet | Agus et al. Liew, Emily Kumar, Perumal Samyudia, Yudi |
| author_sort | Liew, Emily |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In this paper, we address the progress, challenges and prospect of modeling mixing in bioreactor by the utilization of Computational Fluid Dynamics (CFD). Efficient operation of bioreactor is essential in the biotechnological process, not only to ensure good yield but also to maintain consistent product quality. Process modeling technique has frequently been adopted in the bioreactor design, optimization and control as well as in scale-up process. One of the critical issues in bioreactor modeling is the need to overcome the mass and heat transfer limitations imposed on the bioreactor performance, particularly the close interaction between fluid flow and the biological reactions. CFD can be applied to overcome this obstacles by integrating the flow rates between adjacent zones, and fluid mechanical quantities, as the integration of mixing phenomena into the bioreactor modeling is considered a vital aspect in the efficient design and scale-up of bioreactor system. |
| first_indexed | 2025-11-14T06:29:09Z |
| format | Conference Paper |
| id | curtin-20.500.11937-10249 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:29:09Z |
| publishDate | 2009 |
| publisher | CUTSE 2009 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-102492017-01-30T11:17:44Z CFD Approach for Non-Ideally Mixed Bioreactor Modeling Liew, Emily Kumar, Perumal Samyudia, Yudi Agus et al. mixing bioreactor CFD In this paper, we address the progress, challenges and prospect of modeling mixing in bioreactor by the utilization of Computational Fluid Dynamics (CFD). Efficient operation of bioreactor is essential in the biotechnological process, not only to ensure good yield but also to maintain consistent product quality. Process modeling technique has frequently been adopted in the bioreactor design, optimization and control as well as in scale-up process. One of the critical issues in bioreactor modeling is the need to overcome the mass and heat transfer limitations imposed on the bioreactor performance, particularly the close interaction between fluid flow and the biological reactions. CFD can be applied to overcome this obstacles by integrating the flow rates between adjacent zones, and fluid mechanical quantities, as the integration of mixing phenomena into the bioreactor modeling is considered a vital aspect in the efficient design and scale-up of bioreactor system. 2009 Conference Paper http://hdl.handle.net/20.500.11937/10249 CUTSE 2009 fulltext |
| spellingShingle | mixing bioreactor CFD Liew, Emily Kumar, Perumal Samyudia, Yudi CFD Approach for Non-Ideally Mixed Bioreactor Modeling |
| title | CFD Approach for Non-Ideally Mixed Bioreactor Modeling |
| title_full | CFD Approach for Non-Ideally Mixed Bioreactor Modeling |
| title_fullStr | CFD Approach for Non-Ideally Mixed Bioreactor Modeling |
| title_full_unstemmed | CFD Approach for Non-Ideally Mixed Bioreactor Modeling |
| title_short | CFD Approach for Non-Ideally Mixed Bioreactor Modeling |
| title_sort | cfd approach for non-ideally mixed bioreactor modeling |
| topic | mixing bioreactor CFD |
| url | http://hdl.handle.net/20.500.11937/10249 |